Hale E M, Hinsdill R D
Antimicrob Agents Chemother. 1975 Jan;7(1):74-81. doi: 10.1128/AAC.7.1.74.
Staphylococcin 462 is a proteinaceous inhibitor produced by Staphylococcus aureus strain 462. In broth cultures, susceptible S. aureus strain 140 and 19 respond to treatment with the bacteriocin by stopping growth and cell division. Examination of macromolecular synthesis by measuring the incorporation of radioactive precursors revealed that S. aureus 140 stops synthesizing protein immediately. After exposure to staphylococcin 462, the synthesis of deoxyribonucleic acid and ribonucleic acid is quickly inhibited also, but not as completely. Treatment of S. aureus 140 with the inhibitor causes a rapid drop in cellular adenosine 5'-triphosphate level to about 60% of control levels. Of the 70 strains of gram-positive bacteria tested for susceptibility to staphylococcin 462, 24 (34%), distributed among 7 genera, were susceptible.
葡萄球菌素462是由金黄色葡萄球菌菌株462产生的一种蛋白质类抑制剂。在肉汤培养物中，敏感的金黄色葡萄球菌菌株140和19在接受该细菌素处理后停止生长和细胞分裂。通过测量放射性前体的掺入来检测大分子合成，结果显示金黄色葡萄球菌140立即停止合成蛋白质。暴露于葡萄球菌素462后，脱氧核糖核酸和核糖核酸的合成也很快受到抑制，但不完全。用该抑制剂处理金黄色葡萄球菌140会导致细胞三磷酸腺苷水平迅速下降至对照水平的约60%。在测试对葡萄球菌素462敏感性的70株革兰氏阳性菌中，有24株（34%）分布在7个属中，对其敏感。
