多烯大环内酯类抗生素念珠菌素和假丝菌素各组分的生物合成顺序：作为细胞内组分的大环内酯苷元
Sequence of biosynthesis of the components of the polyene macrolides candidin and candihexin: macrolide aglycones as intracellular components.
作者信息
Martin J F, McDaniel L E
出版信息
Antimicrob Agents Chemother. 1975 Feb;7(2):208-14. doi: 10.1128/AAC.7.2.208.
Abstract
A sequential formation of the single components of the polyene macrolide candidin complex (heptaene) has been found. In addition to the three components occurring in the candidin complex at the end of the fermentation, two other "early" all-trans heptaene components have been characterized. They exist only during the phase of active biosynthesis of candidin. Two of the components of the polyene macrolide candihexin complex (hexaene) that have been described as lacking amino sugar were the only intracellular (mycelium-associated) components observed under conditions in which no extracellular polyene remained attached to the producing cell. The results indicate that glycosylation of the macrolide ring takes place during the secretion process.
摘要
已发现多烯大环内酯类念珠菌素复合物（七烯）的单一成分是按顺序形成的。除了在发酵结束时念珠菌素复合物中出现的三种成分外，还鉴定出另外两种“早期”全反式七烯成分。它们仅存在于念珠菌素的活跃生物合成阶段。多烯大环内酯类制霉菌素复合物（六烯）中已被描述为缺乏氨基糖的两种成分，是在没有细胞外多烯附着于产生细胞的条件下观察到的仅有的细胞内（与菌丝体相关）成分。结果表明，大环内酯环的糖基化发生在分泌过程中。
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