巴贝斯虫病中的抗原变异：原因不止一个吗？

Antigenic variation in babesiosis: is there more than one 'why'?

作者信息

Allred D R

机构信息

Department of Pathobiology, University of Florida, Gainesville, FL 32611-0880, USA.

出版信息

Microbes Infect. 2001 May;3(6):481-91. doi: 10.1016/s1286-4579(01)01404-6.

DOI:10.1016/s1286-4579(01)01404-6

PMID:11377210

Abstract

Many intraerythrocytic hemoparasites survive the host immune system through rapid antigenic variation. Among babesial parasites antigenic variation has been demonstrated convincingly only for Babesia bovis and Babesia rodhaini. The molecular basis for antigenic variation in babesial parasites and its possible connection with cytoadherence and sequestration are discussed.

摘要

许多红细胞内血液寄生虫通过快速的抗原变异在宿主免疫系统中存活下来。在巴贝斯虫寄生虫中，仅对牛巴贝斯虫和罗得西亚巴贝斯虫令人信服地证明了抗原变异。本文讨论了巴贝斯虫寄生虫抗原变异的分子基础及其与细胞黏附和滞留的可能联系。