Allred David R, Al-Khedery Basima
Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611-0880, USA.
Mol Biochem Parasitol. 2004 Mar;134(1):27-35. doi: 10.1016/j.molbiopara.2003.09.012.
Babesia bovis is a protozoal hemoparasite of cattle which behaves in certain crucial respects like Plasmodium falciparum, despite being phylogenetically distant and having many differences in its life cycle. The shared behavioral attributes of rapid antigenic variation and cytoadhesion/sequestration are thought to contribute significantly to immune evasion, establishment of persistent infections, and disease pathology. Although differing in their genetic and biochemical strategies for achieving these behaviors, information from studies of each parasite may further our understanding of the overall host-parasite interaction. In this review we contrast the molecular basis and 'genetic logic' for these critical behaviors in the two parasites, with emphasis on the biology of B. bovis.
牛巴贝斯虫是牛的一种原生动物血液寄生虫，尽管在系统发育上距离较远且生命周期有许多差异，但在某些关键方面的行为类似于恶性疟原虫。快速抗原变异和细胞黏附/滞留的共同行为属性被认为对免疫逃避、持续性感染的建立以及疾病病理有显著贡献。尽管它们实现这些行为的遗传和生化策略不同，但来自对每种寄生虫研究的信息可能会增进我们对整体宿主-寄生虫相互作用的理解。在这篇综述中，我们对比了这两种寄生虫中这些关键行为的分子基础和“遗传逻辑”，重点是牛巴贝斯虫的生物学特性。
