单纯疱疹病毒感染

Herpes simplex virus infections.

作者信息

Whitley R J, Roizman B

机构信息

Department of Pediatrics, Microbiology, and Medicine, University of Alabama at Birmingham, Children's Hospital, 1600 7th Avenue South, Birmingham, AL 35233, USA.

出版信息

Lancet. 2001 May 12;357(9267):1513-8. doi: 10.1016/S0140-6736(00)04638-9.

DOI:10.1016/S0140-6736(00)04638-9

PMID:11377626

Abstract

Herpes simplex virus (HSV) is a member of the herpesviridae family. Recognised since ancient Greek times, the virus frequently infects human beings, causing a range of diseases from mild uncomplicated mucocutaneous infection to those that are life threatening. In the past 50 years, substantial advances in our knowledge of the molecular biology of HSV have led to insights into disease pathogenesis and management. This review provides a contemporary interpretation of the biological properties, function, epidemiology, and treatment of HSV diseases.

摘要

单纯疱疹病毒（HSV）是疱疹病毒科的成员。自古希腊时代起就已被认识，该病毒经常感染人类，可引发一系列疾病，从轻度单纯的黏膜皮肤感染到危及生命的疾病。在过去50年里，我们对HSV分子生物学的认识取得了重大进展，从而深入了解了疾病的发病机制和治疗方法。本综述对HSV疾病的生物学特性、功能、流行病学和治疗进行了当代解读。