Puvanendran K, Goh K L
Department of Neurology, Sleep Disorder Unit, Singapore General Hospital, 169608, Singapore.
Sleep Res Online. 1999;2(1):11-4.
We have no information on snoring and obstructive sleep apnea (OSA) in our population, which is predominantly Chinese. Our perception is that sleep apnea syndrome is more common than the 2-4% prevalence (Young et al., 1993) often quoted, judging from the experience in our sleep disorder unit. We studied the snorers in an adult population in Singapore and then went on to see how many snorers suffer pathological apnea and sleep apnea syndrome. Room partners, 220 of them aged 30-60 years, were interviewed for their observation of snoring among each other. 106 consecutive habitual loud snorers of a similar age group in the same population were studied with polysomnography in our sleep laboratory. An apnea index greater than 5 was considered pathological. 24.09% were loud habitual snorers. 87.5% of loud habitual snorers had significant obstructive apneas on the polysomnogram and 72% of these apneics complained of excessive daytime sleepiness (EDS). Given the clinical observation that all apneics snored, by extrapolating these figures, we guess that sleep apnea syndrome affects about 15% of the population. Multiple Sleep Latency Tests validated EDS in our cases with clinical hypersomnia. Hypersomnolence was significantly related to the poor delta wave sleep. Contrary to what was believed, OSA occurred predominantly in stage 1 and 2 non-rapid eye movement (NREM) sleep rather than in REM sleep. The frequent arousals prevented sleep going beyond stage 1 and 2.
我们所研究的人群主要为华人,目前尚无该人群打鼾及阻塞性睡眠呼吸暂停(OSA)方面的信息。从我们睡眠障碍科的经验来看,我们感觉睡眠呼吸暂停综合征比通常引用的2%-4%的患病率(Young等人,1993年)更为常见。我们对新加坡成年人群中的打鼾者进行了研究,进而了解有多少打鼾者患有病理性呼吸暂停和睡眠呼吸暂停综合征。我们对220名年龄在30至60岁之间的同屋伙伴进行了访谈,询问他们相互之间打鼾的观察情况。在我们的睡眠实验室中,对同一人群中106名年龄相仿的连续习惯性大声打鼾者进行了多导睡眠图研究。呼吸暂停指数大于5被视为病理性的。24.09%为习惯性大声打鼾者。在多导睡眠图上,87.5%的习惯性大声打鼾者有明显的阻塞性呼吸暂停,其中72%的呼吸暂停者抱怨白天过度嗜睡(EDS)。鉴于临床观察到所有呼吸暂停者都打鼾,通过推断这些数据,我们猜测睡眠呼吸暂停综合征影响约15%的人群。多次睡眠潜伏期测试验证了我们临床诊断为发作性睡病的患者存在EDS。发作性睡病与慢波睡眠差显著相关。与之前的认知相反,OSA主要发生在非快速眼动(NREM)睡眠的第1和第2阶段,而非快速眼动睡眠期。频繁的觉醒使睡眠无法进入第3和第4阶段。