Osiyemi O O, Dowdy L M, Mallon S M, Cleary T
University of Miami School of Medicine, Department of Medicine, FL 33136, USA.
Transplantation. 2001 May 15;71(9):1343-6. doi: 10.1097/00007890-200105150-00029.
Cerebral phaeohyphomycosis is a rare disease caused by dematiaceous (darkly pigmented) fungi. Cladophialophora species are highly neurotropic, and Cladophialophora bantiana (synonym=Xylohypha bantiana or C. trichoides) is the most commonly identified agent. Most reported cases of cerebral phaeohyphomycosis have occurred in immunocompetent patients; however, some case reports and experimental data have suggested that cellular immune deficiency is a risk factor. We report a case of pulmonary and cerebral phaeohyphomycosis in a cardiac transplant patient due to a newly identified species of Cladophialophora. Optimal management includes both antifungal therapy and surgery.
脑暗色丝孢霉病是一种由暗色（色素沉着深）真菌引起的罕见疾病。枝顶孢属真菌具有高度嗜神经性，其中班替枝顶孢（同义词=班替木霉或毛状枝顶孢）是最常鉴定出的病原体。大多数报告的脑暗色丝孢霉病病例发生在免疫功能正常的患者中；然而，一些病例报告和实验数据表明细胞免疫缺陷是一个危险因素。我们报告了一例心脏移植患者发生的肺和脑暗色丝孢霉病，病原体为新鉴定出的一种枝顶孢属真菌。最佳治疗方案包括抗真菌治疗和手术治疗。
