Becker Ulrik, Grønbaek Morten, Johansen Ditte, Sørensen Thorkild I A
Copenhagen Centre for Prospective Population Studies, Danish Epidemiology Science Centre at the Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark.
Hepatology. 2002 Apr;35(4):868-75. doi: 10.1053/jhep.2002.32101.
Although there is a well-known relationship between total alcohol intake and future risk for cirrhosis, other factors such as the type of alcohol consumed are sparsely studied. The aim of this study was to assess the effects of wine compared with other types of alcoholic beverages on risk for alcohol-induced cirrhosis. In 3 prospective studies, 30,630 participants from the Copenhagen area were followed-up for a total observation time of 417,325 person-years. Information on weekly intake of beer, wine, and spirits, and sex, age, body mass index, smoking habits, and education was obtained from questionnaires. The primary outcome measures were first admission or death, with alcohol-induced cirrhosis obtained from death certificates and from the National Hospital Discharge Register. Data were analyzed by means of multiplicative Poisson regression models. We confirmed the increasing risk for cirrhosis with increasing alcohol intake. Individuals who drank more than 5 drinks per day had a relative risk of 14 to 20 for developing cirrhosis compared with non- or light drinkers. However, compared with individuals who drank no wine (relative risk set at 1.0), individuals drinking 16% to 30% wine of their total intake had a relative risk of 0.4 (95% confidence limits, 0.3-0.6) and those drinking 51% or more of wine had a relative risk of 0.3 (95% confidence limits, 0.2-0.5) for developing cirrhosis. In conclusion, the results suggest that a high intake of all 3 types of alcohol conveys an increased risk for cirrhosis, but wine drinkers are at a lower risk than beer and spirits drinkers.
尽管总酒精摄入量与未来患肝硬化的风险之间存在众所周知的关联，但其他因素，如所饮用酒精的类型，却鲜有研究。本研究的目的是评估葡萄酒与其他类型酒精饮料相比，对酒精性肝硬化风险的影响。在3项前瞻性研究中，对哥本哈根地区的30630名参与者进行了随访，总观察时间为417325人年。通过问卷调查获取了有关啤酒、葡萄酒和烈酒的每周摄入量，以及性别、年龄、体重指数、吸烟习惯和教育程度的信息。主要结局指标是首次入院或死亡，酒精性肝硬化的诊断依据死亡证明和国家医院出院登记册。数据采用乘法泊松回归模型进行分析。我们证实了肝硬化风险随酒精摄入量增加而增加。与不饮酒或轻度饮酒者相比，每天饮酒超过5杯的个体患肝硬化的相对风险为14至20。然而，与不饮用葡萄酒的个体（相对风险设定为1.0）相比，饮用葡萄酒占总摄入量16%至30% 的个体患肝硬化的相对风险为0.4（95%置信区间，0.3 - 0.6），而饮用葡萄酒占总摄入量51%或更多的个体患肝硬化的相对风险为0.3（95%置信区间，0.2 - 0.5）。总之，结果表明，所有3种类型的酒精摄入量高都会增加患肝硬化的风险，但饮用葡萄酒的人比饮用啤酒和烈酒的人风险更低。
