用利巴韦林治疗急性尼帕病毒性脑炎。

Treatment of acute Nipah encephalitis with ribavirin.

作者信息

Chong H T, Kamarulzaman A, Tan C T, Goh K J, Thayaparan T, Kunjapan S R, Chew N K, Chua K B, Lam S K

机构信息

Department of Medicine, University of Malaya Medical Centre, Lembah Pantai, Kuala Lumpur, Malaysia.

出版信息

Ann Neurol. 2001 Jun;49(6):810-3. doi: 10.1002/ana.1062.

DOI:10.1002/ana.1062

PMID:11409437

Abstract

Nipah virus, a newly identified paramyxovirus caused a severe outbreak of encephalitis in Malaysia with high fatalities. We report an open-label trial of ribavirin in 140 patients, with 54 patients who were managed prior to the availability of ribavirin or refused treatment as control. There were 45 deaths (32%) in the ribavirin arm; 29 deaths (54%) occurred in the control arm. This represents a 36% reduction in mortality (p = 0.011). There was no associated serious side effect. This study suggests that ribavirin is able to reduce the mortality of acute Nipah encephalitis.

摘要

尼帕病毒是一种新发现的副粘病毒，在马来西亚引发了严重的脑炎疫情，致死率很高。我们报告了一项针对140名患者的利巴韦林开放标签试验，其中54名患者在有利巴韦林之前就已接受治疗或拒绝治疗，作为对照组。利巴韦林组有45人死亡（32%）；对照组有29人死亡（54%）。这意味着死亡率降低了36%（p = 0.011）。且没有相关的严重副作用。这项研究表明，利巴韦林能够降低急性尼帕脑炎的死亡率。