UvrA和UvrB水解ATP在核苷酸切除修复过程中的作用。
Role of ATP hydrolysis by UvrA and UvrB during nucleotide excision repair.
作者信息
Goosen N, Moolenaar G F
机构信息
Laboratory of Molecular Genetics, Leiden Institute of Chemistry, Leiden University, The Netherlands.
出版信息
Res Microbiol. 2001 Apr-May;152(3-4):401-9. doi: 10.1016/s0923-2508(01)01211-6.
Nucleotide excision repair in eubacteria is a process that repairs DNA damages by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent reaction that requires the UvrA, UvrB and UvrC proteins. Both UvrA and UvrB are ATPases, with UvrA having two ATP binding sites which have the characteristic signature of the family of ABC proteins and UvrB having one ATP binding site that is structurally related to that of helicases.
真细菌中的核苷酸切除修复是一个通过去除包含损伤的12 - 13聚体寡核苷酸来修复DNA损伤的过程。受损DNA的识别和切割是一个多步骤的ATP依赖反应，需要UvrA、UvrB和UvrC蛋白。UvrA和UvrB都是ATP酶，UvrA有两个ATP结合位点，具有ABC蛋白家族的特征性标志，UvrB有一个ATP结合位点，其结构与解旋酶的ATP结合位点相关。
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