室内环境中产生有毒代谢物的细菌和真菌。
Toxic-metabolite-producing bacteria and fungus in an indoor environment.
作者信息
Peltola J, Andersson M A, Haahtela T, Mussalo-Rauhamaa H, Rainey F A, Kroppenstedt R M, Samson R A, Salkinoja-Salonen M S
机构信息
Division of Microbiology, Department of Applied Chemistry and Microbiology, University of Helsinki, FIN-00014 University of Helsinki, Finland.
出版信息
Appl Environ Microbiol. 2001 Jul;67(7):3269-74. doi: 10.1128/AEM.67.7.3269-3274.2001.
Abstract
Toxic-metabolite-emitting microbes were isolated from the indoor environment of a building where the occupant was suffering serious building-related ill-health symptoms. Toxic substances soluble in methanol and inhibitory to spermatozoa at <10 microg (dry weight) ml(-1) were found from six bacterial isolates and one fungus. The substances from isolates of Bacillus simplex and from isolates belonging to the actinobacterial genera Streptomyces and Nocardiopsis were mitochondriotoxic. These substances dissipated the mitochondrial membrane potential (Deltapsi) of boar spermatozoa. The substances from the Streptomyces isolates also swelled the mitochondria. The substances from isolates of Trichoderma harzianum Rifai and Bacillus pumilus damaged the cell membrane barrier function of sperm cells.
摘要
从一名居住者出现严重的与建筑物相关的健康不良症状的建筑物室内环境中分离出了产生有毒代谢物的微生物。从六种细菌分离株和一种真菌中发现了可溶于甲醇且在浓度低于10微克（干重）/毫升时对精子有抑制作用的有毒物质。来自简单芽孢杆菌分离株以及属于放线菌属链霉菌属和诺卡氏菌属的分离株的物质具有线粒体毒性。这些物质使公猪精子的线粒体膜电位（ΔΨ）消散。来自链霉菌分离株的物质还使线粒体肿胀。来自哈茨木霉里法伊分离株和短小芽孢杆菌的物质破坏了精子细胞的细胞膜屏障功能。
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本文引用的文献
1
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Environ Toxicol Pharmacol. 1997 Feb 15;3(1):57-63. doi: 10.1016/s1382-6689(96)00140-8.
2
Structure and composition of biological slimes on paper and board machines.纸张和纸板机上生物粘液的结构和组成。
Appl Environ Microbiol. 1994 Feb;60(2):641-53. doi: 10.1128/aem.60.2.641-653.1994.
3
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4
How to establish a lasting relationship with your host: lessons learned from Mycobacterium spp.如何与宿主建立持久关系：从分枝杆菌属汲取的经验教训
Immunol Cell Biol. 2000 Aug;78(4):301-10. doi: 10.1046/j.1440-1711.2000.00938.x.
5
Toxic lactonic lipopeptide from food poisoning isolates of Bacillus licheniformis.来自地衣芽孢杆菌食物中毒分离株的有毒内酯环脂肽。
Eur J Biochem. 2000 Jul;267(13):4068-74. doi: 10.1046/j.1432-1033.2000.01467.x.
6
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Infect Immun. 2000 Jan;68(1):165-9. doi: 10.1128/IAI.68.1.165-169.2000.
7
Mitochondria and cell death. Mechanistic aspects and methodological issues.线粒体与细胞死亡。机制层面与方法学问题。
Eur J Biochem. 1999 Sep;264(3):687-701. doi: 10.1046/j.1432-1327.1999.00725.x.
8
Ionophoretic properties and mitochondrial effects of cereulide: the emetic toxin of B. cereus.蜡样芽胞杆菌呕吐毒素cereulide的离子电泳特性及线粒体效应
Eur J Biochem. 1999 Jul;263(1):112-7. doi: 10.1046/j.1432-1327.1999.00476.x.
9
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Bioorg Med Chem. 1999 May;7(5):895-9. doi: 10.1016/s0968-0896(99)00024-3.
10
Indoor air-related effects and airborne (1 --> 3)-beta-D-glucan.室内空气相关影响与空气传播的（1 --> 3）-β-D-葡聚糖。
Environ Health Perspect. 1999 Jun;107 Suppl 3(Suppl 3):501-3. doi: 10.1289/ehp.99107s3501.
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