抗大鼠IgE抗体诱导的正常大鼠肺功能变化
Pulmonary function changes in normal rats induced by antibody against rat IgE.
作者信息
Casey F B, Abboa-Offei B E
出版信息
Clin Exp Immunol. 1979 Jun;36(3):473-8.
Abstract
Changes in pulmonary function, as measured by airway conductance and dynamic compliance, in normal rats have been provoked by the administration of a rabbit antisera prepared against rat IgE myeloma protein. The response is specific in that neither anti-IgG nor normal rabbit serum induced pulmonary changes. Pre-treatment with disodium cromoglycate inhibits the bronchospasm in a dose related manner. In addition, drug protection can be demonstrated with as long 1 hr pre-dosing.
摘要
通过气道传导率和动态顺应性测量的正常大鼠肺功能变化，已由给予针对大鼠IgE骨髓瘤蛋白制备的兔抗血清引发。该反应具有特异性，因为抗IgG和正常兔血清均未诱导肺部变化。用色甘酸钠预处理以剂量相关方式抑制支气管痉挛。此外，在给药前长达1小时即可证明药物保护作用。
相似文献
1
Pulmonary function changes in normal rats induced by antibody against rat IgE.抗大鼠IgE抗体诱导的正常大鼠肺功能变化
Clin Exp Immunol. 1979 Jun;36(3):473-8.
2
[Estimation of anti IgE-induced asthma in guinea pigs by the use of Mead's apparatus, and its application in the examination of disodium cromoglycate].
Nihon Kyobu Shikkan Gakkai Zasshi. 1986 Nov;24(11):1240-6.
3
Induction of an auto-anti-IgE response in rats. III. Inhibition of a specific IgE response.大鼠自身抗IgE反应的诱导。III. 特异性IgE反应的抑制。
Immunology. 1989 Mar;66(3):428-33.
4
Effect of disodium cromoglycate on anti-IgE induced early and late skin response in humans.
Clin Allergy. 1985 Mar;15(2):167-71.
5
Evaluation of an antiallergic agent (disodium cromoglycate) in rat conjunctiva using monoclonal IgE antibody.
Ophthalmic Res. 1987;19(4):240-4. doi: 10.1159/000265501.
6
[Inhibitory effect of disodium cromoglycate (Lomudal) inhalation antigen provocation in atopic asthma; result of a single-blind trial].
Schweiz Med Wochenschr. 1971 Jul 17;101(28):1034-8.
7
8
Induction of allergen-specific IgE and IgG responses by anti-idiotypic antibodies.抗独特型抗体诱导变应原特异性IgE和IgG反应
J Immunol. 1989 May 15;142(10):3411-5.
9
10
Immunological safety assessments of anti-IgE antibody which is detached from therapeutic immunoadsorbents for removing IgE.
J Biomed Mater Res. 1989 Nov;23(11):1343-54. doi: 10.1002/jbm.820231110.
引用本文的文献
1
2
Role of mast cells in anaphylaxis. Evidence for the importance of mast cells in the cardiopulmonary alterations and death induced by anti-IgE in mice.肥大细胞在过敏反应中的作用。肥大细胞在抗IgE诱导的小鼠心肺改变及死亡中重要性的证据。
J Clin Invest. 1989 Apr;83(4):1375-83. doi: 10.1172/JCI114025.
本文引用的文献
1
Mechanics of respiration in unanesthetized guinea pigs.未麻醉豚鼠的呼吸力学
Am J Physiol. 1958 Feb;192(2):364-8. doi: 10.1152/ajplegacy.1958.192.2.364.
2
On-line analog computer for dynamic lung compliance and pulmonary resistance.
J Appl Physiol. 1969 Feb;26(2):248-52. doi: 10.1152/jappl.1969.26.2.248.
3
Airway dilatation and constriction in spontaneously breathing guinea pigs.
J Pharmacol Exp Ther. 1972 Jan;180(1):98-109.
4
The use of IgE mediated responses as a pharmacologic test system. The effect of disodium cromoglycate in respiratory and cutaneous reactions and on the electrocardiograms of rhesus monkeys.将IgE介导的反应用作药理学测试系统。色甘酸钠对恒河猴呼吸和皮肤反应以及心电图的影响。
Int Arch Allergy Appl Immunol. 1971;41(4):592-603. doi: 10.1159/000230552.
5
Immediate-type hypersensitivity in dogs: cutaneous, anaphylactic, and respiratory responses to ascaris.犬的速发型超敏反应：对蛔虫的皮肤、过敏和呼吸道反应。
J Lab Clin Med. 1970 Aug;76(2):181-9.
6
Airway responses to histamine, acetylcholine, and antigen in sensitized guinea pigs.致敏豚鼠气道对组胺、乙酰胆碱和抗原的反应。
J Lab Clin Med. 1974 Aug;84(2):225-34.
7
The inhibition by dexamethasone and disodium cromoglycate of anaphylactic bronchoconstriction in the rat.地塞米松和色甘酸钠对大鼠过敏性支气管收缩的抑制作用。
Br J Pharmacol. 1972 Sep;46(1):56-65. doi: 10.1111/j.1476-5381.1972.tb06848.x.
8
Pharmacological studies on active bronchial anaphylaxis in the rat.大鼠支气管过敏性反应的药理学研究。
Can J Physiol Pharmacol. 1974 Dec;52(6):1119-25. doi: 10.1139/y74-147.
9
The interaction of IgE with rat basophilic leukemia cells. II. Quantitative aspects of the binding reaction.免疫球蛋白E与大鼠嗜碱性白血病细胞的相互作用。II. 结合反应的定量方面。
J Exp Med. 1974 Dec 1;140(6):1676-95. doi: 10.1084/jem.140.6.1676.
10
Zotero 插件