抗大鼠IgE抗体诱导的正常大鼠肺功能变化
Pulmonary function changes in normal rats induced by antibody against rat IgE.
作者信息
Casey F B, Abboa-Offei B E
出版信息
Clin Exp Immunol. 1979 Jun;36(3):473-8.
Abstract
Changes in pulmonary function, as measured by airway conductance and dynamic compliance, in normal rats have been provoked by the administration of a rabbit antisera prepared against rat IgE myeloma protein. The response is specific in that neither anti-IgG nor normal rabbit serum induced pulmonary changes. Pre-treatment with disodium cromoglycate inhibits the bronchospasm in a dose related manner. In addition, drug protection can be demonstrated with as long 1 hr pre-dosing.
摘要
通过气道传导率和动态顺应性测量的正常大鼠肺功能变化，已由给予针对大鼠IgE骨髓瘤蛋白制备的兔抗血清引发。该反应具有特异性，因为抗IgG和正常兔血清均未诱导肺部变化。用色甘酸钠预处理以剂量相关方式抑制支气管痉挛。此外，在给药前长达1小时即可证明药物保护作用。
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