Sarrell E M, Mandelberg A, Cohen H A
Pediatric and Adolescent Ambulatory Community Clinic of General Health Services, Hairis 7 Moshav Gan-Haim, 44910 Israel.
Arch Pediatr Adolesc Med. 2001 Jul;155(7):796-9. doi: 10.1001/archpedi.155.7.796.
To determine the efficacy and tolerance of Otikon Otic Solution (Healthy-On Ltd, Petach-Tikva, Israel), a naturopathic herbal extract (containing Allium sativum, Verbascum thapsus, Calendula flores, and Hypericum perforatum in olive oil), compared with Anaesthetic (Vitamed Pharmaceutical Ltd, Benyamina, Israel) ear drops (containing ametocaine and phenazone in glycerin) in the management of ear pain associated with acute otitis media (AOM).
Children between the ages of 6 and 18 years who experienced ear pain (otalgia) and who were diagnosed with eardrum problems associated with AOM were randomly assigned to be treated with Otikon or Anaesthetic ear drops, which were instilled into the external canal(s) of the affected ear(s). Ear pain was assessed using 2 visual analog scales: a linear scale and a color scale. Pain assessment took place throughout the course of 3 days. The mean score of pain reduction was used to measure outcome.
Primary pediatric community ambulatory centers.
One hundred three children aged 6 to 18 years who were diagnosed with otalgia associated with AOM.
Each of the 2 treatment groups were comparable on the basis of age, sex, laterality of AOM, and the effectiveness of ameliorating symptoms of otalgia. The 2 groups were also comparable to each other in the initial ear pain score and in the scores at each application of Otikon or Anaesthetic drops. There was a statistically significant improvement in ear pain score throughout the course of the study period (P =.007).
Otikon, an ear drop formulation of naturopathic origin, is as effective as Anaesthetic ear drops and was proven appropriate for the management of AOM-associated ear pain.
比较奥蒂康耳用溶液（以色列佩塔提克瓦市健康源有限公司生产）与麻醉性耳滴剂（以色列贝尼亚米纳市维塔美制药有限公司生产）治疗急性中耳炎（AOM）相关耳痛的疗效和耐受性。奥蒂康耳用溶液是一种天然草药提取物（橄榄油中含有大蒜、毛蕊花、金盏花和贯叶连翘）。
对6至18岁经历耳痛（耳痛）且被诊断为与AOM相关的鼓膜问题的儿童，随机分配接受奥蒂康或麻醉性耳滴剂治疗，将药物滴入患耳的外耳道。使用2种视觉模拟量表评估耳痛：线性量表和颜色量表。在3天的疗程中进行疼痛评估。用疼痛减轻的平均评分来衡量结果。
初级儿科社区门诊中心。
103名6至18岁被诊断为与AOM相关耳痛的儿童。
两个治疗组在年龄、性别、AOM的患侧以及缓解耳痛症状的有效性方面具有可比性。两组在初始耳痛评分以及每次使用奥蒂康或麻醉性滴剂后的评分方面也具有可比性。在整个研究期间，耳痛评分有统计学上的显著改善（P = 0.007）。
奥蒂康，一种天然来源的耳滴剂配方，与麻醉性耳滴剂效果相同，被证明适用于治疗与AOM相关的耳痛。
