补骨脂酚：补骨脂中一种对他克林诱导的Hep G2细胞毒性具有肝保护作用的化合物。
Bakuchiol: a hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells.
作者信息
Cho H, Jun J Y, Song E K, Kang K H, Baek H Y, Ko Y S, Kim Y C
机构信息
MRRC and College of Pharmacy, Wonkwang University, Iksan, Korea.
出版信息
Planta Med. 2001 Nov;67(8):750-1. doi: 10.1055/s-2001-18347.
Bioassay-guided fractionation of the H(2)O extract of the seeds of Psoralea corylifolia furnished one hepatoprotective compound, bakuchiol (1), together with two moderately active compounds, bakuchicin (2) and psoralen (3), on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC(50) values of compounds 1 - 3 are 1.0, 47.0, 50.0 microg/ml, respectively. Silymarin as a positive control showed the EC(50) value with 5.0 microg/ml.
补骨脂种子水提取物的生物活性导向分离得到一种具有肝保护作用的化合物补骨脂酚（1），以及两种活性中等的化合物补骨脂素（2）和补骨脂内酯（3），它们对他克林诱导的人肝源性Hep G2细胞毒性有作用。化合物1 - 3的半数有效浓度（EC50）值分别为1.0、47.0、50.0微克/毫升。水飞蓟素作为阳性对照，其半数有效浓度（EC50）值为5.0微克/毫升。
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