Tran M T, Mitchell T M, Kennedy D T, Giles J T
School of Pharmacy, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA.
Pharmacotherapy. 2001 Jul;21(7):797-806. doi: 10.1592/phco.21.9.797.34564.
Coenzyme Q10 (CoQ10) has a pathophysiologic role in many disease states. The purpose of this review is to provide recommendations regarding the safety, efficacy, and dosing of CoQ10 in the management of chronic heart failure (CHF), angina, and hypertension.
Literature pertaining to the safety and efficacy of CoQ10 specifically in cardiovascular indications was reviewed. We used relevant clinical trials, articles, reviews, and letters that were selected from a literature search of the MEDLINE database (1974-2000), Micromedex Healthcare Series, and the Natural Medicines Comprehensive Database.
Coenzyme Q10 administered orally has favorable actions in the described cardiovascular conditions and appears to be safe and well tolerated in the adult population. Issues concerning optimum target dosages, potential interactions, monitoring parameters, and the role of CoQ10 as a monotherapeutic agent need to be investigated further. Favorable effects of CoQ10 on ejection fraction, exercise tolerance, cardiac output, and stroke volume are demonstrated in the literature; thus, the use of CoQ10 as adjuvant therapy in patients with CHF may be supported.
Coenzyme Q10 therapy in angina and hypertension cannot be substantiated until additional clinical trials demonstrate consistent beneficial effects. However, CoQ10 may be recommended as adjuvant therapy in selected patients with CHE At this time, CoQ10 should not be recommended as monotherapy or first-line therapy in any disease state.
辅酶Q10（CoQ10）在多种疾病状态中具有病理生理作用。本综述的目的是提供关于CoQ10在慢性心力衰竭（CHF）、心绞痛和高血压管理中的安全性、有效性及剂量的建议。
对专门涉及CoQ10在心血管适应症方面安全性和有效性的文献进行了综述。我们使用了从MEDLINE数据库（1974 - 2000年）、Micromedex医疗保健系列和天然药物综合数据库的文献检索中选出的相关临床试验、文章、综述和信函。
口服CoQ10在所描述的心血管疾病中具有有益作用，并且在成年人群中似乎是安全且耐受性良好的。关于最佳目标剂量、潜在相互作用、监测参数以及CoQ10作为单一治疗药物的作用等问题需要进一步研究。文献表明CoQ10对射血分数、运动耐量、心输出量和每搏输出量有有利影响；因此，CoQ10作为CHF患者的辅助治疗可能是有依据的。
在更多临床试验证明有一致的有益效果之前，CoQ10治疗心绞痛和高血压的依据尚不充分。然而，CoQ10可被推荐作为部分CHF患者的辅助治疗。目前，在任何疾病状态下，CoQ10都不应被推荐作为单一疗法或一线疗法。
