Satyamurti S, Drachman D B, Slone F
Science. 1975 Mar 14;187(4180):955-7. doi: 10.1126/science.1145181.
In order to block acetylcholine receptors of muscle, the alpha toxin of the Formosan cobra (Naja naja atra) was given intravenously to rats. Electrophysiological and pharmacological changes typical of myasthenia gravis were recorded, including decremental responses to repetitive stimuli, curare sensitivity, neostigmine reversal, and posttetanic phenomena. This model supports the concept that a reduction of available acetylcholine receptors may play an important role in myasthenia gravis.
为了阻断肌肉的乙酰胆碱受体，将台湾眼镜蛇（眼镜蛇）的α毒素静脉注射给大鼠。记录了重症肌无力典型的电生理和药理学变化，包括对重复刺激的递减反应、箭毒敏感性、新斯的明逆转和强直后现象。该模型支持这样一种观点，即可用乙酰胆碱受体的减少可能在重症肌无力中起重要作用。
