Cameron J L, Zuidema G D, Margolis S
Surgery. 1975 Jun;77(6):754-63.
Twelve patients with prior episodes of alcoholic pancreatitis and hyperlipemia were admitted to a metabolic ward during a quiescent period. By lipid feeding (316 to 894 Gm. per day), significant hypertriglyceridemia (greater than 600 mg. per 100 ml.) was induced in 11 of the 12 patients. Seven of the 11 patients with hypertriglyceridemia developed abdominal pain similar to but not as severe as that experienced during prior attacks of pancreatitis. Four of the seven patients with abdominal pain developed serum amylase elevations, and, of the remaining three, one had a serum lipase elevation and one a urinary amylase elevation. Alcohol ingestion is known to increase serum triglyceride levels in many individuals. A prior study demonstrated that 41 percent of the patients presenting to our hospital with alcoholic pancreatitis had serum triglyceride elevations. The data from the present study suggest that increased serum triglycerides act as an important intermediary in the pathogenesis of acute pancreatitis in some alcoholic patients.
12例既往有酒精性胰腺炎和高脂血症发作史的患者在病情静止期被收入代谢病房。通过给予脂质（每天316至894克），12例患者中的11例出现了显著的高甘油三酯血症（每100毫升大于600毫克）。11例高甘油三酯血症患者中有7例出现了与既往胰腺炎发作时相似但程度较轻的腹痛。7例腹痛患者中有4例血清淀粉酶升高，其余3例中，1例血清脂肪酶升高，1例尿淀粉酶升高。众所周知，饮酒会使许多人的血清甘油三酯水平升高。先前的一项研究表明，我院收治的酒精性胰腺炎患者中有41%血清甘油三酯升高。本研究的数据表明，血清甘油三酯升高在一些酒精性患者急性胰腺炎的发病机制中起重要的中介作用。
