吲哚美辛、酮洛芬与豚鼠黄体退化
Indomethacin, ketoprofen and corpus luteum regression in the guinea-pig.
作者信息
Donovan B T
出版信息
Br J Pharmacol. 1975 Feb;53(2):225-7. doi: 10.1111/j.1476-5381.1975.tb07352.x.
Abstract
1 The accelerated regression of the corpora lutea normally produced by glass beads inserted unilaterally into the uterus of the guinea-pig early in the oestrous cycle was prevented when the beads were filled with indomethacin or ketoprofen. 2 Luteal regression was enhanced by the placement of beads in both horns of the uterus. When empty beads were placed in one horn of the uterus and drug-filled beads in the other, indomethacin blocked regression in both ovaries whereas ketoprofen was ineffective. 3 Indomethacin probably blocks luteal regression by inhibition of prostaglandin syntheses in the uterus.
摘要
在发情周期早期，将玻璃珠单侧植入豚鼠子宫时，正常情况下黄体的加速退化会被阻止，若玻璃珠中填充吲哚美辛或酮洛芬。
将珠子置于子宫双侧角可增强黄体退化。当空珠子置于子宫一侧角而药物填充的珠子置于另一侧角时，吲哚美辛可阻止双侧卵巢的退化，而酮洛芬则无效。
吲哚美辛可能通过抑制子宫中前列腺素的合成来阻止黄体退化。
相似文献
1
Indomethacin, ketoprofen and corpus luteum regression in the guinea-pig.吲哚美辛、酮洛芬与豚鼠黄体退化
Br J Pharmacol. 1975 Feb;53(2):225-7. doi: 10.1111/j.1476-5381.1975.tb07352.x.
2
Uterine distension and the function of the corpora lutea in the guinea-pig.豚鼠的子宫扩张与黄体功能
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本文引用的文献
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Uterine distension and the function of the corpora lutea in the guinea-pig.豚鼠的子宫扩张与黄体功能
J Physiol. 1966 Oct;186(3):503-15. doi: 10.1113/jphysiol.1966.sp008052.
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Oestrogen and progesterone and the function of the corpora lutea in the guinea-pig.雌激素、孕酮与豚鼠黄体的功能
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J Physiol. 1972 May;223(1):69-88. doi: 10.1113/jphysiol.1972.sp009835.
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Identification of prostaglandin F2-alpha released by distension of guinea-pig uterus in vitro.体外豚鼠子宫扩张释放的前列腺素F2-α的鉴定
Nature. 1971 Apr 23;230(5295):526-8. doi: 10.1038/230526a0.
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The formation of prostaglandins by the guinea-pig uterus and the effect of indomethacin.
Adv Biosci. 1973;9:631-4.
8
Elongation of oestrous cycle in the guinea-pig following subcutaneous or intra-uterine administration of indomethacin.皮下或子宫内给予吲哚美辛后豚鼠发情周期的延长。
Br J Pharmacol. 1973 Sep;49(1):98-105.
9
Indomethacin lengthens the oestrous cycle of the guinea-pig when given orally with oestrogen or when implanted within the uterine lumen.当与雌激素一起口服或植入子宫腔时，吲哚美辛会延长豚鼠的发情周期。
Prostaglandins. 1973 Aug;4(2):251-61. doi: 10.1016/0090-6980(73)90043-9.
10
An attempt to inhibit the uterine luteolysin in the guinea-pig.抑制豚鼠子宫溶黄体素的尝试。
J Physiol. 1972 Apr;222(2):169P-170P.
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