Donovan B T
Br J Pharmacol. 1975 Feb;53(2):225-7. doi: 10.1111/j.1476-5381.1975.tb07352.x.
1 The accelerated regression of the corpora lutea normally produced by glass beads inserted unilaterally into the uterus of the guinea-pig early in the oestrous cycle was prevented when the beads were filled with indomethacin or ketoprofen. 2 Luteal regression was enhanced by the placement of beads in both horns of the uterus. When empty beads were placed in one horn of the uterus and drug-filled beads in the other, indomethacin blocked regression in both ovaries whereas ketoprofen was ineffective. 3 Indomethacin probably blocks luteal regression by inhibition of prostaglandin syntheses in the uterus.
在发情周期早期，将玻璃珠单侧植入豚鼠子宫时，正常情况下黄体的加速退化会被阻止，若玻璃珠中填充吲哚美辛或酮洛芬。
将珠子置于子宫双侧角可增强黄体退化。当空珠子置于子宫一侧角而药物填充的珠子置于另一侧角时，吲哚美辛可阻止双侧卵巢的退化，而酮洛芬则无效。
吲哚美辛可能通过抑制子宫中前列腺素的合成来阻止黄体退化。
