Greenwood B, Kerry P J
Br J Pharmacol. 1975 Feb;53(2):305-7. doi: 10.1111/j.1476-5381.1975.tb07363.x.
By implanting a Teflon chamber subcutaneously into a sheep a mild aseptic inflammatory lesion was produced from which wound fluid could be sampled daily. The prostaglandin content of this wound fluid was examined. Prostaglandin E2 activity was found in all samples, and a peak was apparent on the fourth or fifth day after producing the lesion. The amount of prostaglandin activity appeared to be unrelated to the total number of polymorphs in the fluid or to the volume of this exudate.
通过将一个聚四氟乙烯腔室皮下植入绵羊体内,产生了一个轻度无菌性炎性损伤,每天可从中采集伤口液体。检测了该伤口液体中的前列腺素含量。在所有样本中均发现了前列腺素E2活性,并且在损伤产生后的第四或第五天出现了一个峰值。前列腺素活性的量似乎与液体中多形核白细胞的总数或这种渗出液的体积无关。