Levy S B
Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
Emerg Infect Dis. 2001;7(3 Suppl):512-5. doi: 10.3201/eid0707.017705.
The recent entry of products containing antibacterial agents into healthy households has escalated from a few dozen products in the mid-1990s to more than 700 today. Antibacterial products were developed and have been successfully used to prevent transmission of disease-causing microorganisms among patients, particularly in hospitals. They are now being added to products used in healthy households, even though an added health benefit has not been demonstrated. Scientists are concerned that the antibacterial agents will select bacteria resistant to them and cross-resistant to antibiotics. Moreover, if they alter a person's microflora, they may negatively affect the normal maturation of the T helper cell response of the immune system to commensal flora antigens; this change could lead to a greater chance of allergies in children. As with antibiotics, prudent use of these products is urged. Their designated purpose is to protect vulnerable patients.
近年来，含抗菌剂的产品进入健康家庭的情况不断增加，从20世纪90年代中期的几十种产品，激增至如今的700多种。抗菌产品最初是为预防致病微生物在患者间传播而研发的，并且在医院中得到了成功应用。现在这些产品甚至被添加到健康家庭使用的产品中，尽管尚未证明其能带来额外的健康益处。科学家们担心，抗菌剂会筛选出对其产生耐药性且对抗生素具有交叉耐药性的细菌。此外，如果它们改变了人体的微生物群落，可能会对免疫系统中T辅助细胞对共生菌群抗原的正常成熟反应产生负面影响；这种变化可能会增加儿童患过敏症的几率。与抗生素一样，人们被敦促谨慎使用这些产品。它们的指定用途是保护易感染患者。
