Cornu Catherine, Grange Clémence, Regalin Amanda, Munier Justine, Ounissi Sonia, Reynaud Natane, Kassai-Koupai Behrouz, Sallet Pierre, Nony Patrice
INSERM, CIC1407, 69500, Bron, France.
UMR 5558, Université Claude Bernard Lyon 1, 69100, Lyon, France.
Sports Med Open. 2020 Apr 28;6(1):20. doi: 10.1186/s40798-020-00247-w.
Non-steroidal anti-inflammatory drugs (NSAIDs) are medications that are frequently used by athletes. There may also be some abuse of these substances, although it is unclear whether NSAIDs in fact enhance performance. We performed a systematic review and meta-analysis to evaluate the effect of NSAIDs on sport performance indices.
We selected randomized trials from the PubMed and Cochrane Library databases investigating the effects of NSAIDs on sport performance. Volunteers could be healthy adult men and women. Any NSAID, administered by any route, taken prior to any type of exercise, and for any duration could be used. The control intervention could be a placebo, an active substance, or no intervention. We included double-blind, single-blind, and open-label studies. The primary outcome was the maximum performance in exercises as defined in each study. The secondary outcomes were the time until self-reported exhaustion and the self-reported pain.
Among 1631 records, we retained thirteen parallel-group and ten crossover studies, totaling 366 and 148 subjects, respectively. They were disparate regarding treatments, dose and duration, and the type of exercise. There was neither significant difference in the maximum performance between NSAIDs and control groups nor in the time until exhaustion nor in self-perceived pain.
The existence of an ergogenic effect of NSAIDs on sport performance indices was unable to be concluded, since the level of evidence of the studies is low, the doses tested, and the exercises performed are very heterogeneous and far from those observed in real-life practices. More studies are required.
非甾体抗炎药（NSAIDs）是运动员经常使用的药物。这些药物也可能存在一些滥用情况，尽管尚不清楚NSAIDs是否真的能提高运动成绩。我们进行了一项系统评价和荟萃分析，以评估NSAIDs对运动成绩指标的影响。
我们从PubMed和Cochrane图书馆数据库中筛选了调查NSAIDs对运动成绩影响的随机试验。志愿者可以是健康的成年男性和女性。可以使用任何途径给药、在任何类型运动前服用、持续任何时长的任何NSAIDs。对照干预可以是安慰剂、活性物质或无干预。我们纳入了双盲、单盲和开放标签研究。主要结局是每项研究中定义的运动中的最大表现。次要结局是自我报告的疲劳时间和自我报告的疼痛。
在1631条记录中，我们保留了13项平行组研究和10项交叉研究，分别共有366名和148名受试者。它们在治疗、剂量和持续时间以及运动类型方面存在差异。NSAIDs组和对照组在最大表现、疲劳时间或自我感知疼痛方面均无显著差异。
由于研究的证据水平较低、所测试的剂量以及所进行的运动非常异质且与实际生活中的情况相差甚远，因此无法得出NSAIDs对运动成绩指标具有促力效应的结论。需要更多的研究。
