Seyoum B, Mengistu Z, Berhanu P, Abdulkadir J, Feleke Y, Worku Y, Ayana G
Endocrinology and Metabolism Unit, Department of Internal Medicine, Faculty of Medicine, Addis Ababa University, Addis Ababa.
Ethiop Med J. 2001 Apr;39(2):123-31.
A total of 302 diabetic patients were selected from regular attendants of the Tikur Anbessa Hospital (TAH) diabetic clinic to determine the prevalence of retinopathy from December 1994 to March 1995. The mean age was 41.4 +/- 14.4 years (range 14-85). There were 160 males (53%) and 142 females (47%). One hundred forty (46%) were type 1 and 162 (53.6%) were type 2. The mean duration of diabetes was 9.4 +/- 5.4 years and the mean Hemoglobin Alc (HbAlc) was 10.4 + 2.2%. On the day of the examination the mean fasting blood glucose (FBG) and random blood glucose (RBG) were 195.5 +/- 79.9 mg/dl and 273.1 +/- 114.5 mg/dl respectively. The mean serum total cholesterol, triglycerides, LDL, VLDL and GDL were 166.5 +/- 45.5 mg/dl, 129.9 +/- 92.4 mg/dl, 94.5 +/- 36.4 mg/dl, 24.4 +/- 15.1 mg/dl and 44.3 +/- 11.5 mg/dl respectively. The overall prevalence of retinopathy was 37.8% out of which 108 patients (36.1%) had background retinopathy and 5 patients (1.7%) had proliferative retinopathy. The retina could not be visualized in three patients because of dense cataract. Retinopathy correlated positively with age, duration of diabetes and blood pressure respectively, however no significant correlation was seen with mean total HgAlc and serum lipids. Prevalence of retinopathy was comparable in type 1 and type 2 (p > 0.05). The prevalence of retinopathy in our patients relative to the duration of diabetes mellitus is high. Therefore, improving facilities for the diagnosis and treatment of retinopathy is recommended.
1994年12月至1995年3月期间,从提库尔·安贝萨医院(TAH)糖尿病门诊的定期就诊者中选取了302名糖尿病患者,以确定视网膜病变的患病率。平均年龄为41.4±14.4岁(范围14 - 85岁)。男性160名(53%),女性142名(47%)。140名(46%)为1型糖尿病,162名(53.6%)为2型糖尿病。糖尿病平均病程为9.4±5.4年,平均糖化血红蛋白(HbAlc)为10.4 + 2.2%。检查当天,平均空腹血糖(FBG)和随机血糖(RBG)分别为195.5±79.9mg/dl和273.1±114.5mg/dl。平均血清总胆固醇、甘油三酯、低密度脂蛋白、极低密度脂蛋白和高密度脂蛋白分别为166.5±45.5mg/dl、129.9±92.4mg/dl、94.5±36.4mg/dl、24.4±15.1mg/dl和44.3±11.5mg/dl。视网膜病变的总体患病率为37.8%,其中108例患者(36.1%)患有背景性视网膜病变,5例患者(1.7%)患有增殖性视网膜病变。由于白内障严重,3例患者的视网膜无法看清。视网膜病变分别与年龄、糖尿病病程和血压呈正相关,但与平均总糖化血红蛋白和血脂无显著相关性。1型和2型糖尿病患者的视网膜病变患病率相当(p>0.05)。相对于糖尿病病程,我们患者中视网膜病变的患病率较高。因此,建议改善视网膜病变的诊断和治疗设施。