Anan K, Mitsuyama S, Tamae K, Nishihara K, Iwashita T, Abe Y, Ihara T, Nakahara S, Katsumoto F, Toyoshima S
Department of Surgery, Kitakyushu Municipal Medical Centre, Kitakyushu, Fukuoka 802-0077, Japan.
Eur J Surg Oncol. 2001 Aug;27(5):459-63. doi: 10.1053/ejso.2001.1142.
The effectiveness of breast-conserving therapy for mucinous carcinoma has not been well documented. We examined clinical and pathological features of cases to determine whether patients with mucinous carcinoma were suitable candidates for this treatment.
Cases of pure type (n=52) and mixed type (n=24) mucinous carcinomas were reviewed with emphasis on the risk factors associated with local recurrences after breast-conserving therapy.
Large pure mucinous carcinomas had a low incidence of extensive intraductal spreading (EIS). An inverse correlation existed between the incidence of EIS and tumour size (P<0.05). Comedo type EIS was infrequent (11%) in pure mucinous carcinoma. Incidences of lymphatic vessel invasion (4%) and nodal involvement (4%) were lower in pure mucinous carcinoma than in mixed carcinoma (P<0.05). No nodal involvement occurred in patients with pure mucinous carcinoma less than 3 cm in diameter.
Patients with pure mucinous carcinomas, except those invading the local skin, are suitable candidates for breast-conserving therapy. Most pure mucinous carcinomas, including a large tumour up to 5 cm in diameter, can be treated with this therapy.
保乳治疗对黏液腺癌的有效性尚无充分记录。我们研究了病例的临床和病理特征，以确定黏液腺癌患者是否适合这种治疗。
回顾了52例纯型和24例混合型黏液腺癌病例，重点关注保乳治疗后与局部复发相关的危险因素。
大型纯黏液腺癌广泛导管内播散（EIS）的发生率较低。EIS发生率与肿瘤大小呈负相关（P<0.05）。粉刺型EIS在纯黏液腺癌中不常见（11%）。纯黏液腺癌的淋巴管侵犯（4%）和淋巴结受累（4%）发生率低于混合型黏液腺癌（P<0.05）。直径小于3 cm的纯黏液腺癌患者未发生淋巴结受累。
除侵犯局部皮肤的患者外，纯黏液腺癌患者适合保乳治疗。大多数纯黏液腺癌，包括直径达5 cm的大型肿瘤，都可以用这种治疗方法。
