Hamilton M, Card I R, Wallis G G, Mahmoud M R
Psychopharmacology (Berl). 1979 Aug 8;64(2):225-9. doi: 10.1007/BF00496067.
A double-blind trial was carried out comparing the effects of decanoates of flupenthixol and fluphenazine on the symptoms, ward behaviour and functional capacity in occupational therapy in 51 chronic schizophrenic patients. The patients were carefully selected on the basis of rigid criteria for diagnoses. To exclude nonresponders to neuroleptics the patients were first taken off neuroleptic drugs and only those who appeared to show deterioration were included in the trial. The dosage of drugs was varied according to clinical indications. The length of the trial was initially 4 months and 31 patients were followed for an additional 4 months. To ensure reliability multiple assessments were made at the start and the end of the trial. Most of the statistical tests showed no differences between the treatments, but some of those relating to affective symptoms showed an advantage for flupenthixol as compared with fluphenazine. There were no differences in the incidence of extra-pyramidal side-effects which required treatment in only 32% of the patients on each drug.
对51例慢性精神分裂症患者进行了一项双盲试验，比较氟哌噻吨癸酸酯和氟奋乃静癸酸酯对症状、病房行为及职业治疗功能能力的影响。患者根据严格的诊断标准精心挑选。为排除对抗精神病药物无反应者，患者首先停用抗精神病药物，仅将那些似乎病情恶化的患者纳入试验。药物剂量根据临床指征调整。试验最初为期4个月，31例患者又随访了4个月。为确保可靠性，在试验开始和结束时进行了多次评估。大多数统计检验显示治疗组间无差异，但一些与情感症状相关的检验显示，与氟奋乃静相比，氟哌噻吨具有优势。锥体外系副作用的发生率无差异，每种药物治疗的患者中仅32%出现此类副作用。
