Metzger A, Mukasa G, Shankar A H, Ndeezi G, Melikian G, Semba R D
Department of International Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA.
Am J Trop Med Hyg. 2001 Aug;65(2):115-9. doi: 10.4269/ajtmh.2001.65.115.
Although antioxidant status has been implicated in the pathogenesis of malaria, these factors need further characterization. A longitudinal study was conducted involving 273 children 1-10 years of age with acute, uncomplicated malaria in Kampala, Uganda. Plasma vitamin A, carotenoids, and vitamin E were measured at enrollment and on day 7. Malaria parasitemia was measured at enrollment, on day 3, and on day 7. Malaria parasitemia had completely cleared in 57.1% and 85.3% of children by day 3 and day 7, respectively. Plasma vitamin A, alpha-carotene, beta-carotene, lycopene, lutein/zeaxanthin, and vitamin E were depressed at enrollment and increased by day 7. Multivariate analyses showed that higher plasma lycopene concentrations at enrollment were associated with clearance of parasitemia between enrollment and day 3 (odds ratio = 1.46, 95% confidence interval = 1.07-2.06, per 0.10 micromol/L of lycopene). This study suggests that children with acute malaria have depressed plasma concentrations of antioxidants, and that higher plasma lycopene is associated with more rapid clearance of malaria parasitemia.
尽管抗氧化状态已被认为与疟疾的发病机制有关，但这些因素仍需进一步明确。在乌干达坎帕拉对273名1至10岁患急性非复杂性疟疾的儿童进行了一项纵向研究。在入组时和第7天测量血浆维生素A、类胡萝卜素和维生素E。在入组时、第3天和第7天测量疟疾寄生虫血症。到第3天和第7天，分别有57.1%和85.3%的儿童疟疾寄生虫血症完全清除。血浆维生素A、α-胡萝卜素、β-胡萝卜素、番茄红素、叶黄素/玉米黄质和维生素E在入组时降低，到第7天升高。多变量分析显示，入组时较高的血浆番茄红素浓度与入组至第3天期间寄生虫血症的清除有关（比值比=1.46，95%置信区间=1.07-2.06，每0.10微摩尔/升番茄红素）。这项研究表明，患急性疟疾的儿童血浆抗氧化剂浓度降低，且较高的血浆番茄红素与疟疾寄生虫血症更快清除有关。
