Lubrano E, Iovino P, Tremolaterra F, Parsons W J, Ciacci C, Mazzacca G
Physical Medicine and Rehabilitation Department, University Federico II, Naples, Italy.
Int J Colorectal Dis. 2001 Aug;16(4):211-5. doi: 10.1007/s003840100299.
Fibromyalgia (FM) syndrome and irritable bowel syndrome (IBS) are functional disorders in which altered somatic and or visceral perception thresholds have been found. The aim of this study was to evaluate the prevalence of FM in a group of patients with IBS and the possible association of FM with patterns and severity of the intestinal disorder. One hundred thirty consecutive IBS patients were studied. The IBS was divided into four different patterns according to the predominant bowel symptom and into three levels of severity using a functional severity index. All patients underwent rheumatological evaluation for number of positive tender points, number of tender and swollen joints, markers of inflammation, and presence of headache and weakness. Moreover, patients' assessments of diffuse pain, mood and sleep disturbance, anxiety, and fatigue were also measured on a visual analogue scale. The diagnosis of FM was made based on American College of Rheumatology classification criteria. Nonparametric tests were used for statistical analysis. Fibromyalgia was found in 20% of IBS patients. No statistical association was found between the presence of FM and the type of IBS but a significant association was found between the presence of FM and severity of the intestinal disorder. The presence of FM in IBS patients seems to be associated only with the severity of IBS. This result confirms previous studies on the association between the two syndromes.
纤维肌痛（FM）综合征和肠易激综合征（IBS）是功能性疾病，在这些疾病中已发现躯体和/或内脏感知阈值发生改变。本研究的目的是评估一组IBS患者中FM的患病率，以及FM与肠道疾病的类型和严重程度之间可能存在的关联。对130例连续的IBS患者进行了研究。根据主要肠道症状将IBS分为四种不同类型，并使用功能严重程度指数将其分为三个严重程度级别。所有患者均接受了风湿病学评估，包括阳性压痛点数量、压痛和肿胀关节数量、炎症标志物以及头痛和虚弱的情况。此外，还使用视觉模拟量表测量了患者对弥漫性疼痛、情绪和睡眠障碍、焦虑以及疲劳的评估。FM的诊断基于美国风湿病学会分类标准。采用非参数检验进行统计分析。在20%的IBS患者中发现了纤维肌痛。未发现FM的存在与IBS类型之间存在统计学关联，但发现FM的存在与肠道疾病的严重程度之间存在显著关联。IBS患者中FM的存在似乎仅与IBS的严重程度相关。这一结果证实了先前关于这两种综合征之间关联的研究。
