Dumont J E, Pécasse F, Maenhaut C
Institute of Interdisciplinary Research, Free University of Brussels, Campus Erasme, 808 route de Lennik, B-1070, Brussels, Belgium.
Cell Signal. 2001 Jul;13(7):457-63. doi: 10.1016/s0898-6568(01)00168-1.
The numerous examples of "crosstalk" between signal transduction pathways reported in the biochemical literature seem to imply a general common response of cells to different stimuli, even when these stimuli act initially on different cascades. This contradicts our knowledge of the specificity of action of extracellular signals in different cell types. This discrepancy is explained by the restricted occurrence of crosstalks in any cell type and by several categories of cell specificity mechanisms, for instance, the specific qualitative and quantitative expression of the various subtypes of signal transduction proteins, the combinatorial control of the cascades with specific sets of regulatory factors and the compartmentation of signal transduction cascades or their elements.
生化文献中报道的信号转导途径之间“串扰”的众多例子似乎暗示了细胞对不同刺激的普遍共同反应，即使这些刺激最初作用于不同的级联反应。这与我们对细胞外信号在不同细胞类型中作用特异性的认识相矛盾。这种差异可以通过任何细胞类型中串扰的有限发生以及几类细胞特异性机制来解释，例如，信号转导蛋白各种亚型的特定定性和定量表达、特定调节因子集对级联反应的组合控制以及信号转导级联反应或其元件的区室化。
