交感神经刺激对麻醉猫胃的胃酸分泌、局部血流量及氧利用的影响。
The effect of sympathetic nerve stimulation on acid secretion, regional blood flows and oxygen usage by stomachs of anaesthetized cats.
作者信息
Grund E R, Reed J D, Sanders D J
出版信息
J Physiol. 1975 Jul;248(3):639-47. doi: 10.1113/jphysiol.1975.sp010993.
Abstract
- Gastric acid secretion, and total gastric and mucosal blood flows (amidopyrine technique) were measured in anaesthetized cats. Oxygen contents of arterial and gastric venous blood were measured using an oximeter. 2. Splanchnic nerve stimulation (10 Hz) significantly reduced the acid output and total gastric and mucosal blood flows produced in response to maximal gastrin pentapeptide infusions. 3. The arterial haemoglobin concentration was significantly reduced during splanchnic nerve stimulation, and this is consistent with the hypothesis that the splanchnic nerve effect is directed against precapillary sphincters. 4. During the period of inhibition, gastric oxygen consumption and acid secretion were reduced to similar degrees. There was no significant change in oxygen extraction by the stomach. 5. It remains possible that the splanchnic nerves directly inhibit the parietal cell activity.
摘要
- 对麻醉猫测量胃酸分泌以及胃和黏膜总血流量（氨基比林技术）。使用血氧计测量动脉血和胃静脉血的氧含量。2. 内脏神经刺激（10赫兹）显著降低了对最大胃泌素五肽输注产生的酸分泌量以及胃和黏膜总血流量。3. 内脏神经刺激期间动脉血红蛋白浓度显著降低，这与内脏神经效应针对毛细血管前括约肌的假说一致。4. 在抑制期间，胃氧消耗量和酸分泌量以相似程度降低。胃的氧摄取没有显著变化。5. 内脏神经直接抑制壁细胞活性仍有可能。
相似文献
1
The effect of sympathetic nerve stimulation on acid secretion, regional blood flows and oxygen usage by stomachs of anaesthetized cats.交感神经刺激对麻醉猫胃的胃酸分泌、局部血流量及氧利用的影响。
J Physiol. 1975 Jul;248(3):639-47. doi: 10.1113/jphysiol.1975.sp010993.
2
The effect of sympathetic nerve stimulation on serum gastrin, gastric acid secretion and mucosal blood flow responses to meat extract stimulation in anaesthetized cats.交感神经刺激对麻醉猫血清胃泌素、胃酸分泌及黏膜血流对肉提取物刺激反应的影响。
J Physiol. 1975 Dec;253(2):493-504. doi: 10.1113/jphysiol.1975.sp011202.
3
Splanchnic nerve inhibition of gastric acid secretion and mucosal blood flow in anaesthetized cats.内脏神经对麻醉猫胃酸分泌和黏膜血流的抑制作用。
J Physiol. 1971 Dec;219(3):555-70. doi: 10.1113/jphysiol.1971.sp009677.
4
Pepsin secretion in the anaesthetized cat and the effect of sympathetic nerve stimulation.麻醉猫的胃蛋白酶分泌及交感神经刺激的影响。
J Physiol. 1976 Sep;260(3):609-27. doi: 10.1113/jphysiol.1976.sp011535.
5
The effect of splanchnic nerve stimulation on gastric acid secretion and mucosal blood flow in the anaesthetized cat.内脏神经刺激对麻醉猫胃酸分泌及黏膜血流的影响。
J Physiol. 1971 Apr;214(1):1-13. doi: 10.1113/jphysiol.1971.sp009415.
6
A review: the agents and actions of sympathetic nerve and catecholamine inhibition of gastric mucosal function.综述：交感神经和儿茶酚胺对胃黏膜功能抑制的作用及相关因子
Agents Actions. 1976 Jul;6(4):385-8. doi: 10.1007/BF01973207.
7
Gastric blood flow in anaesthetized cats.麻醉猫的胃血流量
J Physiol. 1968 Feb;194(3):795-807. doi: 10.1113/jphysiol.1968.sp008435.
8
Pepsin secretion, gastric motility and mucosal blood flow in the anaesthetized cat.麻醉猫的胃蛋白酶分泌、胃动力及黏膜血流
J Physiol. 1971 Jul;216(1):159-70. doi: 10.1113/jphysiol.1971.sp009515.
9
Mechanisms relating gastric acid secretion and mucosal blood flow during gastrin and histamine stimulation.胃泌素和组胺刺激期间胃酸分泌与黏膜血流的相关机制。
J Physiol. 1971 Dec;219(3):571-85. doi: 10.1113/jphysiol.1971.sp009678.
10
Effects of isopropylnoradrenaline on tachyphylaxis of gastrin stimulated gastric acid secretion and mucosal blood flow in the anaesthetized cat.异丙肾上腺素对麻醉猫胃泌素刺激的胃酸分泌速发性耐受和黏膜血流的影响。
J Physiol. 1976 Jan;254(1):153-68. doi: 10.1113/jphysiol.1976.sp011226.
引用本文的文献
1
Oxygen uptake as a determinant of gastric blood flow autoregulation.氧摄取作为胃血流自动调节的一个决定因素。
Dig Dis Sci. 1982 Aug;27(8):675-9. doi: 10.1007/BF01393761.
2
Experimental stress ulcer and gastric catecholamine contents in spontaneously hypertensive rats.自发性高血压大鼠的实验性应激性溃疡与胃内儿茶酚胺含量
Gastroenterol Jpn. 1986 Dec;21(6):567-72. doi: 10.1007/BF02774483.
3
Pepsin secretion in the anaesthetized cat and the effect of sympathetic nerve stimulation.麻醉猫的胃蛋白酶分泌及交感神经刺激的影响。
J Physiol. 1976 Sep;260(3):609-27. doi: 10.1113/jphysiol.1976.sp011535.
4
A review: the agents and actions of sympathetic nerve and catecholamine inhibition of gastric mucosal function.综述：交感神经和儿茶酚胺对胃黏膜功能抑制的作用及相关因子
Agents Actions. 1976 Jul;6(4):385-8. doi: 10.1007/BF01973207.
本文引用的文献
1
Gastric secretion induced by histamine and its relationship to the rate of blood flow.组胺诱导的胃液分泌及其与血流速率的关系。
J Physiol. 1953 Sep;121(3):433-44. doi: 10.1113/jphysiol.1953.sp004956.
2
Inhibition of gastrointestinal movement by sympathetic nerve stimulation: the site of action.交感神经刺激对胃肠运动的抑制作用：作用部位。
J Physiol. 1967 Apr;189(2):317-27. doi: 10.1113/jphysiol.1967.sp008170.
3
Gastric blood flow in anaesthetized cats.麻醉猫的胃血流量
J Physiol. 1968 Feb;194(3):795-807. doi: 10.1113/jphysiol.1968.sp008435.
4
The effect of splanchnic nerve stimulation on gastric acid secretion and mucosal blood flow in the anaesthetized cat.内脏神经刺激对麻醉猫胃酸分泌及黏膜血流的影响。
J Physiol. 1971 Apr;214(1):1-13. doi: 10.1113/jphysiol.1971.sp009415.
5
The adrenergic innervation of the vessels supplying and draining the gastrointestinal tract.供应和引流胃肠道的血管的肾上腺素能神经支配。
Z Zellforsch Mikrosk Anat. 1971;113(1):67-82. doi: 10.1007/BF00331202.
6
Transmitter histochemistry of the sympathetic adrenergic nervous system.交感肾上腺素能神经系统的递质组织化学
Brain Res. 1967 Jun;5(2):125-70. doi: 10.1016/0006-8993(67)90084-4.
7
Splanchnic nerve inhibition of gastric acid secretion and mucosal blood flow in anaesthetized cats.内脏神经对麻醉猫胃酸分泌和黏膜血流的抑制作用。
J Physiol. 1971 Dec;219(3):555-70. doi: 10.1113/jphysiol.1971.sp009677.
8
Adrenergic innervation of the alimentary canal.消化道的肾上腺素能神经支配。
Z Zellforsch Mikrosk Anat. 1971;122(3):357-77. doi: 10.1007/BF00935995.
9
[On the distribution of catecholamines in the human intestines].[关于儿茶酚胺在人体肠道中的分布]
Z Zellforsch Mikrosk Anat. 1967;83(1):133-46.
Zotero 插件