内脏神经对麻醉猫胃酸分泌和黏膜血流的抑制作用。
Splanchnic nerve inhibition of gastric acid secretion and mucosal blood flow in anaesthetized cats.
作者信息
Reed J D, Sanders D J
出版信息
J Physiol. 1971 Dec;219(3):555-70. doi: 10.1113/jphysiol.1971.sp009677.
Abstract
- Efferent electrical splanchnic nerve stimulation will significantly inhibit gastric acid secretion and mucosal blood flow (MBF) stimulated by either large I.V. doses of pentapeptide or histamine, if the rise in blood pressure is prevented.2. Splanchnic stimulation will also reduce the increase in MBF in response to infusions of isopropylnoradrenaline, if the blood pressure rise is prevented.3. Evidence is presented which suggests that the splanchnic nerve inhibitory effect is not due to reducing the amount of stimulant arriving at the gastric mucosa.4. By analysing the responses to histamine, when acid secretion is accompanied by a large MBF relative to the pentapeptide responses, it is suggested that the inhibitory effect of splanchnic nerve stimulation is due to vasoconstriction.5. It remains possible that there is a direct inhibitory effect on the parietal cells.
摘要
如果能防止血压升高，传出性内脏神经电刺激将显著抑制大剂量静脉注射五肽或组胺所刺激的胃酸分泌和黏膜血流量（MBF）。
如果能防止血压升高，内脏神经刺激也会减少异丙肾上腺素输注引起的MBF增加。
有证据表明，内脏神经的抑制作用并非由于减少到达胃黏膜的刺激物数量。
通过分析对组胺的反应，当相对于五肽反应，胃酸分泌伴随着大量MBF时，提示内脏神经刺激的抑制作用是由于血管收缩。
对壁细胞可能存在直接抑制作用仍是有可能的。
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1
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J Pharmacol Exp Ther. 1950 Jun;99(2):171-84.
2
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JAMA. 1963 Mar 23;183:1003-5. doi: 10.1001/jama.1963.63700120006009b.
3
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J Physiol. 1953 Sep;121(3):433-44. doi: 10.1113/jphysiol.1953.sp004956.
4
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Surgery. 1967 Sep;62(3):468-74.
5
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6
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