胃泌素和组胺刺激期间胃酸分泌与黏膜血流的相关机制。
Mechanisms relating gastric acid secretion and mucosal blood flow during gastrin and histamine stimulation.
作者信息
Reed J D, Smy J R
出版信息
J Physiol. 1971 Dec;219(3):571-85. doi: 10.1113/jphysiol.1971.sp009678.
Abstract
- Gastric mucosal blood flow (MBF) and gastric acid secretion have been compared and related during the infusion of a wide dose range of gastrin extracts, pentapeptide (Peptavlon, I.C.I. 50123) and histamine.2. Constancy of increase in mucosal blood flow relative to H(+) secretion was obtained with gastrin stimulation, whereas histamine stimulation produced higher ratios of mucosal blood flow to H(+) secretion, and these ratios declined as each experiment continued.3. The importance of considering only the increase in mucosal blood flow in relation to acid secreted is demonstrated.4. It is concluded that the differences shown in the DeltaMBF/DeltaH(+) with histamine and gastrin stimulation provide further evidence that the amidopyrine clearance technique measures gastric mucosal blood flow.
摘要
在输注多种剂量范围的胃泌素提取物、五肽（培他维隆，帝国化学工业公司50123）和组胺期间，对胃黏膜血流量（MBF）和胃酸分泌进行了比较并探讨了二者之间的关系。
胃泌素刺激时，黏膜血流量相对于H⁺分泌的增加保持恒定，而组胺刺激产生的黏膜血流量与H⁺分泌的比值更高，并且随着每个实验的持续，这些比值会下降。
证明了仅考虑与分泌的酸相关的黏膜血流量增加的重要性。
得出结论，组胺和胃泌素刺激时ΔMBF/ΔH⁺所示的差异提供了进一步的证据，表明氨基比林清除技术可测量胃黏膜血流量。
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