Mechanisms relating gastric acid secretion and mucosal blood flow during gastrin and histamine stimulation.

1. Gastric mucosal blood flow (MBF) and gastric acid secretion have been compared and related during the infusion of a wide dose range of gastrin extracts, pentapeptide (Peptavlon, I.C.I. 50123) and histamine.2. Constancy of increase in mucosal blood flow relative to H(+) secretion was obtained with gastrin stimulation, whereas histamine stimulation produced higher ratios of mucosal blood flow to H(+) secretion, and these ratios declined as each experiment continued.3. The importance of considering only the increase in mucosal blood flow in relation to acid secreted is demonstrated.4. It is concluded that the differences shown in the DeltaMBF/DeltaH(+) with histamine and gastrin stimulation provide further evidence that the amidopyrine clearance technique measures gastric mucosal blood flow.