Peñaherrera-Oviedo Carlos, Moreno-Zambrano Daniel, Palacios Michael, Duarte-Martinez María Carolina, Cevallos Carlos, Gamboa Ximena, Jurado María Beatriz, Tamariz Leonardo, Palacio Ana, Santibañez Rocío
Universidad Catolica de Santiago de Guayaquil, 090112 Guayas, Ecuador.
Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Int J Chronic Dis. 2015;2015:680104. doi: 10.1155/2015/680104. Epub 2015 Aug 4.
Diabetes mellitus is associated with cognitive decline and impaired performance in cognitive function tests among type 1 and type 2 diabetics. Even though the use of tight glucose control has been limited by a reported higher mortality, few reports have assessed the impact of treatment intensity on cognitive function. We conducted a meta-analysis to evaluate if an intensive glucose control in diabetes improves cognitive function, in comparison to standard therapy. We included 7 studies that included type 1 or type 2 diabetics and used standardized tests to evaluate various cognitive function domains. Standardized mean differences (SMDs) were calculated for each domain. We found that type 1 diabetics get no cognitive benefit from a tight glucose control, whereas type 2 diabetics get some benefit on processing speed and executive domains but had worse performances in the memory and attention domains, along with a higher incidence of mortality when using intensive glucose control regimes.
1型和2型糖尿病患者中，糖尿病与认知功能下降以及认知功能测试表现受损有关。尽管严格血糖控制的使用因报告的较高死亡率而受到限制，但很少有报告评估治疗强度对认知功能的影响。我们进行了一项荟萃分析，以评估与标准治疗相比，糖尿病强化血糖控制是否能改善认知功能。我们纳入了7项研究，这些研究包括1型或2型糖尿病患者，并使用标准化测试来评估各个认知功能领域。计算每个领域的标准化平均差（SMD）。我们发现，1型糖尿病患者严格血糖控制未获得认知益处，而2型糖尿病患者在处理速度和执行领域有一定益处，但在记忆和注意力领域表现较差，且使用强化血糖控制方案时死亡率更高。
