Tagawa N, Takano T, Fukata S, Kuma K, Tada H, Izumi Y, Kobayashi Y, Amino N
Clinical Chemistry Laboratory, Kobe Pharmaceutical University, Japan.
Endocr J. 2001 Jun;48(3):345-54. doi: 10.1507/endocrj.48.345.
Androstenediol (5-androsten-3beta, 17beta-diol, ADIOL) and androstenediol 3-sulfate (ADIOLS) are active metabolites of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS), respectively, and have estrogenic activity and immunoregulatory function. We examined serum concentrations of ADIOL, ADIOLS, DHEA, DHEAS and pregnenolone sulfate (5-pregnen-3beta-ol-20-one sulfate, PREGS) in patients with Graves' thyrotoxicosis (male/female 9/14), hypothyroidism (11/20) and in normal controls (14/29). In hypothyroidism serum levels of all these steroids were significantly decreased in both genders. In hyperthyroidism, in contrast, serum levels of ADIOLS (male 1.49 +/- 0.69, female 0.64 +/- 0.31 micromol/l), DHEAS (male 7.43 +/- 3.91, female 5.13 +/- 2.03 micromol/l), and PREGS (male 1.13 +/- 0.58, female 1.07 +/- 0.85 micromol/l) were markedly increased, but serum concentrations of ADIOL and DEHA were not significantly different from controls (ADIOLS male 0.36 +/- 0.33, female 0.14 +/- 0.09 micromol/l; DHEAS male 2.88 +/- 1.70, female 1.86 +/- l1.03pmol/l; PREGS male 0.18 +/- 0.12, female 0.11 +/- 0.08 micromol/l; ADIOL male 3.76 +/- 1.35, female 1.91 +/- 1.17 nmol/l; DHEA male 9.23 +/- 3.49, female 13.5 +/- 10.8nmol/l). Serum concentrations of all these steroids correlated with the serum concentration of the thyroid hormones in these patients. Serum albumin and sex hormone-binding globulin concentrations were not related to these changes in the concentrations of steroids. These findings indicate that serum concentrations of ADIOLS, ADIOL, DHEAS, DHEA and PREGS were decreased in hypothyroidism, whereas serum ADIOLS, DHEAS and PREGS concentrations were increased but ADIOL and DHEA were normal in hyperthyroidism. Thyroid hormone may stimulate the synthesis of these steroids and sulfotransferase is speculated to be increased in hyperthyroidism. Increased ADIOLS might contribute to menstrual disturbances and gynecomastia in hyperthyroidism.
雄烯二醇（5-雄烯-3β，17β-二醇，ADIOL）和硫酸雄烯二醇（ADIOLS）分别是脱氢表雄酮（DHEA）和硫酸脱氢表雄酮（DHEAS）的活性代谢产物，具有雌激素活性和免疫调节功能。我们检测了格雷夫斯甲状腺毒症患者（男/女9/14）、甲状腺功能减退患者（11/20）以及正常对照组（14/29）血清中ADIOL、ADIOLS、DHEA、DHEAS和硫酸孕烯醇酮（5-孕烯-3β-醇-20-酮硫酸酯，PREGS）的浓度。在甲状腺功能减退症中，所有这些类固醇的血清水平在男女两性中均显著降低。相比之下，在甲状腺功能亢进症中，ADIOLS（男性1.49±0.69，女性0.64±0.31微摩尔/升）、DHEAS（男性7.43±3.91，女性5.13±2.03微摩尔/升）和PREGS（男性1.13±0.58，女性1.07±0.85微摩尔/升）的血清水平显著升高，但ADIOL和DHEA的血清浓度与对照组无显著差异（ADIOLS男性0.36±0.33，女性0.14±0.09微摩尔/升；DHEAS男性2.88±1.70，女性1.86±1.03皮摩尔/升；PREGS男性0.18±0.12，女性0.11±0.08微摩尔/升；ADIOL男性3.76±1.35，女性1.91±1.17纳摩尔/升；DHEA男性9.23±3.49，女性13.5±10.8纳摩尔/升）。所有这些类固醇的血清浓度与这些患者甲状腺激素的血清浓度相关。血清白蛋白和性激素结合球蛋白浓度与这些类固醇浓度的变化无关。这些发现表明，甲状腺功能减退症患者血清中ADIOLS、ADIOL、DHEAS、DHEA和PREGS浓度降低，而甲状腺功能亢进症患者血清中ADIOLS、DHEAS和PREGS浓度升高，但ADIOL和DHEA正常。甲状腺激素可能刺激这些类固醇的合成，推测甲状腺功能亢进症中磺基转移酶增加。ADIOLS升高可能导致甲状腺功能亢进症患者的月经紊乱和男性乳房发育。
