Lim J H, Choi D, Cho S K, Kim S H, Lee W J, Lim H K, Park C K, Paik S W, Kim Y I
Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, Seoul 135-710, Korea.
Radiology. 2001 Sep;220(3):669-76. doi: 10.1148/radiol.2203001777.
To correlate the conspicuity of hepatocellular carcinomas and dysplastic nodules on ferumoxides-enhanced magnetic resonance (MR) images with the number of Kupffer cells in the hepatic lesions, as compared with that in background liver in histopathologic findings.
Sixty-nine histopathologically proved moderately or poorly differentiated hepatocellular carcinomas, 10 well-differentiated hepatocellular carcinomas, and 19 dysplastic nodules were retrospectively studied in 68 patients with cirrhosis who underwent ferumoxides-enhanced MR imaging. The contrast-to-noise ratio between the nodules and surrounding parenchyma was calculated at T2-weighted fast spin-echo imaging, and the difference in the number of Kupffer cells between the nodules and surrounding hepatic tissue was calculated histopathologically. The results of MR imaging and histopathologic examination were correlated.
All 69 moderately or poorly differentiated hepatocellular carcinomas had high contrast-to-noise ratios at MR imaging and large differences in the number of Kupffer cells. Six of the 10 well-differentiated hepatocellular carcinomas had contrast-to-noise ratios of zero or nearly zero, and five of these had little difference in the number of Kupffer cells. All 19 dysplastic nodules had contrast-to-noise ratios of zero or nearly zero, and there were virtually no differences in the number of Kupffer cells.
Hepatocellular nodule conspicuity at ferumoxides-enhanced MR imaging depends on differences in the number of Kupffer cells within a nodule and the surrounding cirrhotic liver; moderately or poorly differentiated hepatocellular carcinomas can be distinguished from well-differentiated hepatocellular carcinomas and dysplastic nodules.
在铁氧化物增强磁共振（MR）图像上，将肝细胞癌和发育异常结节的明显程度与肝损伤中库普弗细胞数量相关联，并与组织病理学检查中背景肝组织的情况进行比较。
对68例肝硬化患者进行了回顾性研究，这些患者经组织病理学证实患有69例中分化或低分化肝细胞癌、10例高分化肝细胞癌和19个发育异常结节，并接受了铁氧化物增强MR成像检查。在T2加权快速自旋回波成像时计算结节与周围实质之间的对比噪声比，并通过组织病理学计算结节与周围肝组织之间库普弗细胞数量的差异。将MR成像结果与组织病理学检查结果进行关联分析。
所有69例中分化或低分化肝细胞癌在MR成像时均具有高对比噪声比，且库普弗细胞数量差异较大。10例高分化肝细胞癌中有6例的对比噪声比为零或接近零，其中5例库普弗细胞数量差异不大。所有19个发育异常结节的对比噪声比均为零或接近零，库普弗细胞数量几乎没有差异。
铁氧化物增强MR成像时肝细胞结节的明显程度取决于结节内和周围肝硬化肝脏中库普弗细胞数量的差异；中分化或低分化肝细胞癌可与高分化肝细胞癌和发育异常结节相区分。
