硫代苹果酸金钠对淋巴细胞活化的抑制作用。
Inhibition of lymphocyte activation by gold sodium thiomalate.
作者信息
Hopkins S J, Jayson M I, Van der Zeil P
出版信息
Br J Pharmacol. 1983 Jun;79(2):617-22. doi: 10.1111/j.1476-5381.1983.tb11037.x.
Abstract
Activation of lymphoid cells by both T and B cell mitogens was inhibited by gold sodium thiomalate (GST). The action of GST did not appear to be exerted at early stages of lymphocyte activation. Inhibition by GST was sustained throughout 4 days of culture. The inhibitory effect of GST was reduced at low serum concentrations. Sodium thiomalate and sodium chloroaurate were also able to inhibit lymphocyte activation.
摘要
硫代苹果酸金钠（GST）可抑制T细胞和B细胞有丝分裂原对淋巴细胞的激活作用。GST的作用似乎并非在淋巴细胞激活的早期阶段发挥。在整个4天的培养过程中，GST的抑制作用持续存在。在低血清浓度下，GST的抑制作用会减弱。硫代苹果酸钠和氯金酸钠也能够抑制淋巴细胞的激活。
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