Campbell J W, Cronan J E
Department of Microbiology University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Annu Rev Microbiol. 2001;55:305-32. doi: 10.1146/annurev.micro.55.1.305.
The increase in drug-resistant pathogenic bacteria has created an urgent demand for new antibiotics. Among the more attractive targets for the development of new antibacterial compounds are the enzymes of fatty acid biosynthesis. Although a number of potent inhibitors of microbial fatty acid biosynthesis have been discovered, few of these are clinically useful drugs. Several of these fatty acid biosynthesis inhibitors have potential as lead compounds in the development of new antibacterials. This review encompasses the known inhibitors and prospective targets for new antibacterials.
耐药病原菌的增加产生了对新型抗生素的迫切需求。在新型抗菌化合物开发的更具吸引力的靶点中，脂肪酸生物合成的酶类是其中之一。尽管已经发现了许多强效的微生物脂肪酸生物合成抑制剂，但其中很少有临床上可用的药物。这些脂肪酸生物合成抑制剂中的几种有潜力作为开发新型抗菌药物的先导化合物。这篇综述涵盖了已知的抑制剂和新型抗菌药物的潜在靶点。
