Wiwanitkit V
Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
BMC Fam Pract. 2001;2:2. doi: 10.1186/1471-2296-2-2. Epub 2001 Aug 24.
Alkaline phosphatase (ALP) is an important enzyme mainly derived from the liver, bones and in lesser amounts from intestines, placenta, kidneys and leukocytes. An increase in ALP levels in the serum is frequently associated with a variety of diseases. This study was done in order to determine the diseases associated with a high ALP level among Thai adult hospitalized patients.
A review was made of medical records of inpatients with high ALP level above 1000 IU/L in King Chulalongkorn Memorial Hospital, Thailand from January 1999 to December 1999. Excluded were cases of (a) patients who have bone involvements with malignancies, (b) pediatric patients younger than 15 years old and c) HIV-seropositive patients.
A total of 181 hospitalized patients with eligible medical records were identified (96 males and 85 females, mean age 49.4 +/- 16.1 years). Their ALP levels ranging from 1,001 to 3,067 IU/L, these patients were divided into four groups.
High serum ALP levels in hospitalized patients were commonly found in three major groups having obstructive biliary diseases, infiltrative liver disease and sepsis. The study results were in accordance with previous reports in developed countries. Nonetheless, cholangiocarcionoma and some tropical diseases unique to our setting were also detected in these cases, where there was a marked elevation of serum ALP.
碱性磷酸酶（ALP）是一种重要的酶，主要来源于肝脏、骨骼，少量来源于肠道、胎盘、肾脏和白细胞。血清中ALP水平升高常与多种疾病相关。本研究旨在确定泰国成年住院患者中与高ALP水平相关的疾病。
回顾了泰国朱拉隆功纪念医院1999年1月至1999年12月期间ALP水平高于1000 IU/L的住院患者的病历。排除以下病例：（a）患有骨恶性肿瘤的患者；（b）15岁以下的儿科患者；（c）HIV血清学阳性患者。
共确定了181例符合条件的住院患者病历（男性96例，女性85例，平均年龄49.4±16.1岁）。这些患者的ALP水平在1001至3067 IU/L之间，被分为四组。
住院患者血清ALP水平升高常见于阻塞性胆道疾病、浸润性肝病和脓毒症这三大类疾病。研究结果与发达国家先前的报告一致。尽管如此，在这些血清ALP显著升高的病例中，也检测到了胆管癌和一些我们地区特有的热带疾病。
