Zhang Jinjin, Cao Wei, Zhao Haoan, Guo Sen, Wang Qian, Cheng Ni, Bai Naisheng
College of Food Science and Technology, Northwest University, Xi'an, China.
Bee Product Research Center of Shaanxi, Xi'an, China.
Front Nutr. 2022 Jun 30;9:925351. doi: 10.3389/fnut.2022.925351. eCollection 2022.
Bee pollen is known as a natural nutrient storehouse and plays a key role in many biological processes. Based on the preliminary separation, identification, and characterization of the main active components of Moench. bee pollen (FBP), the protective effects of bee pollen extract (FBPE) on high-fat-diet (HFD) and streptozocin (STZ) induced type II diabetes mellitus (T2DM) was evaluated in this study. The results revealed that FBPE contains 10 active compounds mainly including luteolin (9.46 g/kg), resveratrol (5.25 g/kg), kaemferol (3.67 g/kg), etc. The animal experiment results showed that FBPE could improve HFD-STZ induced T2DM mice. Moreover, the underlying mechanism of the above results could be: (i) FBPE could reduce the inflammation related to phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway, and (ii) the gut microbiota remodeling. The results of correlation analysis showed and indicated positive correlations to tumor necrosis factor-α (TNF-α); , and reported negative correlations to transforming growth factor-β (TGF-β). That FBPE has an outstanding ability to improve T2DM and could be used as a kind of potential functional food for the prevention of T2DM.
蜂花粉被誉为天然营养库，在许多生物过程中发挥着关键作用。基于对小果博落回蜂花粉（FBP）主要活性成分的初步分离、鉴定和表征，本研究评估了蜂花粉提取物（FBPE）对高脂饮食（HFD）和链脲佐菌素（STZ）诱导的II型糖尿病（T2DM）的保护作用。结果显示，FBPE含有10种活性化合物，主要包括木犀草素（9.46 g/kg）、白藜芦醇（5.25 g/kg）、山柰酚（3.67 g/kg）等。动物实验结果表明，FBPE可改善HFD-STZ诱导的T2DM小鼠。此外，上述结果的潜在机制可能为：（i）FBPE可减轻与磷脂酰肌醇3-激酶/蛋白激酶B（PI3K/AKT）信号通路相关的炎症，以及（ii）肠道微生物群重塑。相关性分析结果显示，[此处原文缺失具体指标]与肿瘤坏死因子-α（TNF-α）呈正相关；[此处原文缺失具体指标]与转化生长因子-β（TGF-β）呈负相关。FBPE具有显著改善T2DM的能力，可作为一种潜在的预防T2DM的功能性食品。
