与轮班工作相关的早搏频率和心率变异性变化。
Changes in frequency of premature complexes and heart rate variability related to shift work.
作者信息
van Amelsvoort L G, Schouten E G, Maan A C, Swenne C A, Kok F J
机构信息
Division of Human Nutrition and Epidemiology, Wageningen University, The Netherlands.
出版信息
Occup Environ Med. 2001 Oct;58(10):678-81. doi: 10.1136/oem.58.10.678.
OBJECTIVES
To investigate whether an increased risk of cardiovascular disease might be caused by increased arrhythmogeneity and by unfavourable changes in autonomic cardiac control the changes in the occurrence of premature complexes (PVCs) and in heart rate variability (HRV) were studied in subjects who started to work in shifts.
METHODS
1 Year changes in frequency of PVCs and HRV were measured in 49 shift workers and 22 control subjects working in daytime. All respondents were starting in a new job in integrated circuit or waste incinerator plants.
RESULTS
The incidence of PVC increased significantly in shift workers over the 1 year follow up, compared with daytime workers. The frequency of ventricular extrasystoles increased in 48.9% of the shift workers, and in 27.3% of the daytime workers. The Spearman correlation coefficient between the number of nights worked and the change in PVCs was 0.33 (p=0.004). A small non-significant unfavourable change in HRV was found in both the shift and daytime workers.
CONCLUSIONS
A change in arrhythmogeneity, but not in cardiac autonomic control, might explain the increased risk of cardiovascular disease in shift workers.
目的
为研究心律失常性增加及心脏自主神经控制的不利变化是否可能导致心血管疾病风险增加，对开始从事轮班工作的受试者室性早搏（PVC）发生率及心率变异性（HRV）的变化进行了研究。
方法
对49名轮班工人和22名白天工作的对照受试者测量了PVC频率及HRV的1年变化情况。所有受访者均开始在集成电路厂或垃圾焚烧厂从事新工作。
结果
与白天工作的工人相比，轮班工人在1年随访期间PVC发生率显著增加。48.9%的轮班工人室性早搏频率增加，而白天工作的工人中这一比例为27.3%。夜班工作天数与PVC变化之间的Spearman相关系数为0.33（p = 0.004）。在轮班工人和白天工作的工人中均发现HRV有微小的、无统计学意义的不利变化。
结论
心律失常性的变化而非心脏自主神经控制的变化，可能解释了轮班工人心血管疾病风险增加的原因。
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