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光疗及持续或间断口服琼脂对低体重新生儿高胆红素血症的影响(作者译)

[Variations in hyperbilirrubinemia in low birth weight newborns under phototherapy and continous or discontinous agar oral administration (author's transl)].

作者信息

Colomer J, Moya M, Marco V, De Paredes C, Escrivá F, Vila R

出版信息

An Esp Pediatr. 1975 Jun;8 Suppl 1:27-32.

PMID:1155873
Abstract

Therapeutic attitude in hyperbilirrubinemia is always worth because other infrequent complications but not for this, less important. Phototherapy innocuousness, largely demonstrated, fosters its profilactic use at beginning and not only for those babies with serum bilirrubin over 10 mg % in the first day of life. Previously we have reported positive results with agar oral administration without collateral effects. On this grounds we have planned the following experience in a homogenous group of L.B.W.: one group was fed with agar previously to each formula administration; other group received the same amount of agar but divided in only three administrations in 24 hours; the last group received continuous phototherapy for 96 hours with a white cold fluorescent light from a source of 8-Vita-lite lamp of 40 watts with a intensity of 500 foot candle and 30 lumens. All of these babies weighed less than 2.500 g. and were between 10 and 90 percentil of Lubschenko diagram. They were fed with the same formula and same time table with no infusions, rejecting all that presented any type of pathology. Obstetric conditions were basically identical. This population was randomly divided in four groups. 1) Control group with no profilaxis, but with identical bilirrubin andhematocrit determinations. 2) Group with continuous agar oral administration, 125 mg. before each of the seven formula feeding. 3) Group with discontinuous agar administration, 250 mg. before three of the seven formula feeding. 4) Group with continuous phototherapy for 96 hours. These is initial identification of the groups with statistic signification, and after that a quantitative and sequential evolution of bilirrubin is analized in each group.

摘要

高胆红素血症的治疗态度总是有价值的,因为还有其他不常见的并发症,但并非仅此而已,那些并发症不太重要。光疗的无害性已得到充分证明,这促使其在早期就被预防性使用,而且不仅适用于出生第一天血清胆红素超过10mg%的婴儿。此前我们报告了口服琼脂取得的阳性结果且无副作用。基于此,我们在一组同质的低体重儿中设计了以下实验:一组在每次喂奶前喂琼脂;另一组接受相同量的琼脂,但在24小时内仅分三次给药;最后一组用一盏40瓦的8型维他灯发出的白色冷荧光灯进行96小时的持续光疗,强度为500英尺烛光和30流明。所有这些婴儿体重均不足2500克,处于卢布申科图表的第10至90百分位。他们以相同的配方奶和相同的时间表喂养,无输液,排除所有有任何类型病理情况的婴儿。产科情况基本相同。该人群被随机分为四组。1)无预防措施的对照组,但进行相同的胆红素和血细胞比容测定。2)持续口服琼脂组,在七次喂奶前每次喂125毫克。3)间断口服琼脂组,在七次喂奶中的三次前喂250毫克。4)持续光疗96小时组。这些是对具有统计学意义的组进行初步识别,之后对每组胆红素的定量和连续变化进行分析。

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