Lee L A
Department of Dermatology, University of Colorado School of Medicine, 4200 East Ninth Avenue, Denver, CO 80262, USA.
Curr Rheumatol Rep. 2001 Oct;3(5):391-5. doi: 10.1007/s11926-996-0009-3.
Neonatal lupus is a disease characterized by one or more of the following findings: congenital heart block, cardiomyopathy, cutaneous lupus lesions, hepatobiliary disease, and thrombocytopenia. Accumulating evidence indicates that the disease is probably caused by maternal autoantibodies, particularly autoantibodies of the Ro family. While often initially asymptomatic, mothers tend to develop symptoms of connective tissue disease. This review discusses the recent advances in the understanding of neonatal lupus, its clinical features, therapy, and pathogenesis.
先天性心脏传导阻滞、心肌病、皮肤红斑狼疮病变、肝胆疾病和血小板减少症。越来越多的证据表明，该疾病可能由母体自身抗体引起，尤其是Ro家族的自身抗体。虽然母亲通常最初无症状，但往往会出现结缔组织病的症状。本文综述了新生儿红斑狼疮在认识、临床特征、治疗及发病机制方面的最新进展。
