台湾电镀厂慢性低水平氰化物中毒。
Chronic Low-Level Cyanide Intoxication in an Electroplating Plant in Taiwan.
机构信息
From the Department of Occupational Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan (Dr Fan, Dr Luo, Dr Tsao); College of Medicine, Chang Gung University, Taoyuan, Taiwan (Dr Fan, Dr Yeh, Dr Tsao); New Taipei Municipal TuCheng Hospital, Chang Gung Memorial Hospital, Taoyuan, Taiwan (Dr Luo); Department of Family Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan (Dr Yeh); and Department of Occupational Medicine, Wan Fang Hospital, Taipei Medical University, Taipei City, Taiwan (Dr Huang).
出版信息
J Occup Environ Med. 2022 Sep 1;64(9):777-781. doi: 10.1097/JOM.0000000000002584. Epub 2022 Jun 11.
OBJECTIVE
This study aimed to investigate clinical symptoms among electroplating workers exposed to cyanide.
METHODS
In this study, 26 silver-plating and 51 gold-plating workers completed questionnaires and were tested for urinary thiocyanates. Air cyanide, urinary thiocyanates, and clinical symptoms were compared between workers using Student t and χ 2 test and further analyzed by multivariate linear regression.
RESULTS
Air cyanide and urinary thiocyanate were higher in the silver-plating plant than the gold-plating plant. In both plants, a dose-response relationship was observed between exposure status and thiocyanate levels. Silver-plating workers reported a higher frequency of almond odor detection, nasal bleeding, excessive salivation, skin scalding, and corrosion. Urinary thiocyanates were associated with the plant and exposure status, but not with smoking.
CONCLUSIONS
Our study suggests that silver-plating workers had higher exposure and more symptoms. Urinary thiocyanate may be a useful biomarker for cyanide exposure.
目的
本研究旨在调查接触氰化物的电镀工人的临床症状。
方法
本研究中，26 名镀银工人和 51 名镀金工人完成了问卷调查，并检测了尿硫氰酸盐。通过 Student t 检验和 χ 2 检验比较了工人之间的空气氰化物、尿硫氰酸盐和临床症状，并通过多元线性回归进行了进一步分析。
结果
镀银厂的空气氰化物和尿硫氰酸盐均高于镀金厂。在两个工厂中，暴露状况和硫氰酸盐水平之间均存在剂量反应关系。镀银工人报告说，杏仁味检测、鼻出血、过度流涎、皮肤烫伤和腐蚀的频率更高。尿硫氰酸盐与工厂和暴露状况有关，但与吸烟无关。
结论
我们的研究表明，镀银工人的暴露水平更高，症状更多。尿硫氰酸盐可能是氰化物暴露的有用生物标志物。
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