Oomen C M, Ocké M C, Feskens E J, Kok F J, Kromhout D
Department of Chronic Diseases Epidemiology, National Institute of Public Health and the Environment, Bilthoven, Netherlands.
Am J Clin Nutr. 2001 Oct;74(4):457-63. doi: 10.1093/ajcn/74.4.457.
Data on the relation between alpha-linolenic acid intake and coronary artery disease (CAD) are limited. Other dietary components appear to modify the reported relation between alpha-linolenic acid intake and CAD.
We examined whether dietary alpha-linolenic acid intake was inversely associated with risk of CAD.
We prospectively studied 667 men aged 64-84 y from the Zutphen Elderly Study who were free of CAD at baseline. Dietary intake was assessed by using a cross-check dietary history method.
During the 10-y follow-up, we documented 98 cases of CAD. After adjustment for age, standard coronary risk factors, and intake of trans fatty acids and other nutrients, alpha-linolenic acid intake was not significantly associated with CAD risk. The relative risk of CAD for the highest compared with the lowest tertile of alpha-linolenic acid intake was 1.68 (95% CI: 0.86, 3.29). alpha-Linolenic acid intake from sources containing trans fatty acids was also nonsignificantly, yet positively, associated with CAD risk. alpha-Linolenic acid intake from foods that did not contain trans fatty acids was not associated with CAD risk, the relative risk of CAD for the highest compared with the lowest tertile was 1.15 (95% CI: 0.63, 2.11).
We did not observe a beneficial effect of dietary alpha-linolenic acid intake on the risk of 10-y CAD incidence. Investigating this hypothesis was complicated by the association between intakes of alpha-linolenic acid and trans fatty acids. Given the results of current prospective studies, a protective cardiac effect of alpha-linolenic acid is questionable.
关于α-亚麻酸摄入量与冠状动脉疾病（CAD）之间关系的数据有限。其他饮食成分似乎会改变所报道的α-亚麻酸摄入量与CAD之间的关系。
我们研究了饮食中α-亚麻酸摄入量是否与CAD风险呈负相关。
我们对来自祖特芬老年研究的667名64 - 84岁男性进行了前瞻性研究，这些男性在基线时无CAD。通过交叉核对饮食史方法评估饮食摄入量。
在10年的随访期间，我们记录了98例CAD病例。在调整年龄、标准冠状动脉危险因素以及反式脂肪酸和其他营养素的摄入量后，α-亚麻酸摄入量与CAD风险无显著关联。与α-亚麻酸摄入量最低三分位数相比，最高三分位数的CAD相对风险为1.68（95%CI：0.86，3.29）。来自含有反式脂肪酸来源的α-亚麻酸摄入量与CAD风险也无显著关联，但呈正相关。来自不含反式脂肪酸食物的α-亚麻酸摄入量与CAD风险无关，与最低三分位数相比，最高三分位数的CAD相对风险为1.15（95%CI：0.63，2.11）。
我们未观察到饮食中α-亚麻酸摄入量对10年CAD发病率风险有有益影响。α-亚麻酸摄入量与反式脂肪酸摄入量之间的关联使对这一假设的研究变得复杂。鉴于当前前瞻性研究的结果，α-亚麻酸对心脏的保护作用值得怀疑。
