Vedtofte Mia Sadowa, Jakobsen Marianne U, Lauritzen Lotte, O'Reilly Eilis J, Virtamo Jarmo, Knekt Paul, Colditz Graham, Hallmans Göran, Buring Julie, Steffen Lyn M, Robien Kimberly, Rimm Eric B, Heitmann Berit L
Research Unit for Dietary Studies, Institute of Preventive Medicine,Copenhagen Municipal Hospitals Region H,Copenhagen,Denmark.
Section for Epidemiology, Department of Public Health, Aarhus University,Aarhus,Denmark.
Br J Nutr. 2014 Sep 14;112(5):735-43. doi: 10.1017/S000711451400138X. Epub 2014 Jun 25.
The intake of the mainly plant-derived n-3 PUFA α-linolenic acid (ALA) has been reported to be associated with a lower risk of CHD. However, the results have been inconsistent. Therefore, the objective of the present study was to examine the association between the intake of ALA and the risk of CHD. Potential effect modification by the intake of long-chain n-3 PUFA (n-3 LCPUFA) was also investigated. Data from eight American and European prospective cohort studies including 148 675 women and 80 368 men were used. The outcome measure was incident CHD (CHD event and death). During 4-10 years of follow-up, 4493 CHD events and 1751 CHD deaths occurred. Among men, an inverse association (not significant) between the intake of ALA and the risk of CHD events and deaths was observed. For each additional gram of ALA consumed, a 15 % lower risk of CHD events (hazard ratios (HR) 0·85, 95 % CI 0·72, 1·01) and a 23 % lower risk of CHD deaths (HR 0·77, 95 % CI 0·58, 1·01) were observed. No consistent association was observed among women. No effect modification by the intake of n-3 LCPUFA was observed.
据报道，主要来源于植物的n-3多不饱和脂肪酸α-亚麻酸（ALA）的摄入量与冠心病风险较低有关。然而，结果并不一致。因此，本研究的目的是检验ALA摄入量与冠心病风险之间的关联。同时还研究了长链n-3多不饱和脂肪酸（n-3 LCPUFA）摄入量对潜在效应的修正作用。使用了来自八项美国和欧洲前瞻性队列研究的数据，包括148675名女性和80368名男性。结局指标是冠心病事件（冠心病事件和死亡）。在4至10年的随访期间，发生了4493例冠心病事件和1751例冠心病死亡。在男性中，观察到ALA摄入量与冠心病事件和死亡风险之间存在负相关（不显著）。每多摄入1克ALA，冠心病事件风险降低15%（风险比（HR）0.85，95%置信区间0.72，1.01），冠心病死亡风险降低23%（HR 0.77，95%置信区间0.58，1.01）。在女性中未观察到一致的关联。未观察到n-3 LCPUFA摄入量对效应的修正作用。
