Brigelius-Flohé R, Müller C, Menard J, Florian S, Schmehl K, Wingler K
German Institute of Human Nutrition, Bergholz-Rehbrücke, Germany.
Biofactors. 2001;14(1-4):101-6. doi: 10.1002/biof.5520140114.
Gastro intestinal glutathione peroxidase (GI-GPx) is one of the four distinct mammalian selenoperoxidases. It had been reported to be restricted to the gastrointestinal tract but has more recently been identified also in human liver and some tumor cell lines. GI-GPx ranks high in the hierarchy of selenoproteins. The GI-GPx mRNA rather increases than decreases in selenium deficiency. GI-GPx protein responds poorly to selenium deprivation and increases fast upon resupplementation. Putative biological roles of GI-GPx, e.g. protection against food-born hydroperoxides, redox-regulation of proliferation or apoptosis, and modulation of mucosal immunity, are discussed in the light of cellular and subcellular distribution, transcriptional regulation and observations with k.o. mice.
胃肠道谷胱甘肽过氧化物酶（GI-GPx）是四种不同的哺乳动物硒过氧化物酶之一。据报道，它仅限于胃肠道，但最近在人类肝脏和一些肿瘤细胞系中也被发现。GI-GPx在硒蛋白等级中排名靠前。在硒缺乏时，GI-GPx mRNA增加而非减少。GI-GPx蛋白对硒缺乏反应不佳，但在重新补充硒后迅速增加。根据细胞和亚细胞分布、转录调控以及基因敲除小鼠的观察结果，讨论了GI-GPx的假定生物学作用，例如对食物源性氢过氧化物的保护、增殖或凋亡的氧化还原调节以及粘膜免疫的调节。
