Warheit D B
DuPont Haskell Laboratory, Newark, DE 19714-0050, USA.
J Environ Pathol Toxicol Oncol. 2001;20 Suppl 1:133-41.
The International Agency for Research on Cancer (IARC) recently published a monograph on the evaluation of carcinogenic risks to humans of exposure to crystalline and amorphous silica particles. The IARC Working Group concluded that crystalline silica, in the form of quartz or cristobalite, from occupational sources posed a carcinogenic risk to humans (Category 1). IARC also determined that amorphous silica particles were not classifiable as to its carcinogenicity to humans (Category 3). With regard to amorphous silica, the evaluation was based primarily on the lack of toxicological and epidemiological data for these materials and this was noted in the IARC document. This manuscript is designed to provide a brief summary of the limited inhalation toxicity database related to amorphous silica particulates and to cite a few studies wherein the pulmonary toxicological effects of inhaled crystalline and amorphous silica particles were compared.
国际癌症研究机构（IARC）最近发表了一篇关于评估接触结晶性和无定形二氧化硅颗粒对人类致癌风险的专论。IARC工作组得出结论，职业来源的石英或方石英形式的结晶二氧化硅对人类构成致癌风险（第1类）。IARC还确定，无定形二氧化硅颗粒对人类的致癌性无法分类（第3类）。关于无定形二氧化硅，评估主要基于这些材料缺乏毒理学和流行病学数据，IARC文件中也提到了这一点。本手稿旨在简要总结与无定形二氧化硅颗粒相关的有限吸入毒性数据库，并引用一些比较吸入结晶性和无定形二氧化硅颗粒的肺部毒理学效应的研究。
