通过靶向抗体和生物相容性聚合物的双重功能表面修饰增强多孔硅微球的摄取。
Enhanced uptake of porous silica microparticles by bifunctional surface modification with a targeting antibody and a biocompatible polymer.
机构信息
Department of Chemistry, University of Vermont, Burlington, Vermont 05405, USA.
出版信息
ACS Appl Mater Interfaces. 2010 Sep;2(9):2489-95. doi: 10.1021/am100530t.
Abstract
Strategies were developed by which mesoporous microparticles were modified on their external surfaces with tetraethylene glycol (TEG), a protein, or both, leaving the pore surfaces available for modification with a separate moiety, such as a dye. Only particles bifunctionally modified with both TEG and a cell-specific antibody were taken up specifically by a targeted cancer cell line. In contrast to similarly functionalized nanoparticles, endocytosed microparticles were not contained within a lysosome.
摘要
研究人员开发了一些策略，这些策略可以在介孔微球的外表面上进行修饰，使用的修饰材料有四乙二醇（TEG）、蛋白质或两者兼用，从而使孔表面能够用另一种部分，如染料，进行进一步修饰。只有同时用 TEG 和细胞特异性抗体进行双功能修饰的颗粒才会被特定的靶癌细胞系特异性摄取。与具有类似功能的纳米颗粒不同，内吞的微球不会被包含在溶酶体中。
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本文引用的文献
1
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Angew Chem Int Ed Engl. 1998 Oct 16;37(19):2719-2723. doi: 10.1002/(SICI)1521-3773(19981016)37:19<2719::AID-ANIE2719>3.0.CO;2-6.
2
Multiple core-shell functionalized colloidal mesoporous silica nanoparticles.多个核壳功能化的胶体介孔二氧化硅纳米颗粒。
J Am Chem Soc. 2009 Aug 19;131(32):11361-70. doi: 10.1021/ja809346n.
3
Reversible cell-specific drug delivery with aptamer-functionalized liposomes.通过适配体功能化脂质体实现可逆的细胞特异性药物递送。
Angew Chem Int Ed Engl. 2009;48(35):6494-8. doi: 10.1002/anie.200901452.
4
Controlling and imaging the functional-group distribution on mesoporous silica.
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5
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6
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Langmuir. 2009 Feb 3;25(3):1645-50. doi: 10.1021/la803542v.
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