Nowicki M J, Benning L, Bremer J W, Meyer W A, Hanson C, Brambilla D, Silver S, Kovacs A
University of Southern California, Pediatrics, Los Angeles, California 90033, USA.
J Clin Microbiol. 2001 Oct;39(10):3760-3. doi: 10.1128/JCM.39.10.3760-3763.2001.
Human immunodeficiency virus type 1 (HIV-1) RNA measurements were evaluated within an externally controlled multilaboratory program. Three external standards (1.5 x 10(3) to 1.5 x 10(6) copies/ml) were included in 814 assay runs by four laboratories. Results indicate that HIV-1 RNA levels can be measured with a precision equal to that of the pre-highly active antiretroviral therapy era (standard deviations, +/-0.16 to 0.25 log10 units).
在一个外部控制的多实验室项目中对1型人类免疫缺陷病毒(HIV-1)RNA测量进行了评估。四个实验室在814次检测运行中纳入了三种外部标准品(1.5×10³至1.5×10⁶拷贝/毫升)。结果表明,HIV-1 RNA水平的测量精度与高效抗逆转录病毒治疗前时代相当(标准差为±0.16至0.25 log₁₀单位)。