Woloshin S, Schwartz L M, Moncur M, Gabriel S, Tosteson A N
VA Outcomes Group, White River Junction, Vermont 05009, USA.
Med Decis Making. 2001 Sep-Oct;21(5):382-90. doi: 10.1177/0272989X0102100505.
Patients' values are fundamental to decision models, cost-effectiveness analyses, and pharmacoeconomic analyses. The standard methods used to assess how patients value different health states are inherently quantitative. People without strong quantitative skills (i.e., low numeracy) may not be able to complete these tasks in a meaningful way.
To determine whether the validity of utility assessments depends on the respondent's level of numeracy, the authors conducted in-person interviews and written surveys and assessed utility for the current health for 96 women volunteers. Numeracy was measured using a previously validated 3-item scale. The authors examined the correlation between self-reported health and utility for current health (assessed using the standard gamble, time trade-off, and visual analog techniques) across levels of numeracy. For half of the women, the authors also assessed standard gamble utility for 3 imagined health states (breast cancer, heart disease, and osteoporosis) and asked how much the women feared each disease.
Respondent ages ranged from 50 to 79 years (mean = 63), all were high school graduates, and 52% had a college or postgraduate degree. Twenty-six percent answered 0 or only 1 of the numeracy questions correctly, 37% answered 2 correctly, and 37% answered all 3 correctly. Among women with the lowest level of numeracy, the correlation between utility for current health and self-reported health was in the wrong direction (i.e., worse health valued higher than better health): for standard gamble, Spearman r=-0.16, P = 0.44;for time trade-off, Spearman r=-0.13, P=0.54. Among the most numerate women, the authors observed a fair to moderate positive correlation with both standard gamble (Spearman r=0.22, P=0.19) and time trade-off (Spearman r=0.50, P=0.002). In contrast, using the visual analog scale, the authors observed a substantial correlation in the expected direction at all levels of numeracy (Spearman r= 0.82, 0.50, and 0.60 for women answering 0-1, 2, and 3 numeracy questions, respectively; all Ps < or = 0.003). With regard to the imagined health states, the most feared disease had the lowest utility for 35% of the women with the lowest numeracy compared to 76% of the women with the highest numeracy (P=0.03).
The validity of standard utility assessments is related to the subject's facility with numbers. Limited numeracy may be an important barrier to meaningfully assessing patients' values using the standard gamble and time trade-off techniques.
患者的价值观对于决策模型、成本效益分析和药物经济学分析至关重要。用于评估患者如何评价不同健康状态的标准方法本质上是定量的。没有很强定量技能(即低算术能力)的人可能无法以有意义的方式完成这些任务。
为了确定效用评估的有效性是否取决于受访者的算术水平,作者进行了面对面访谈和书面调查,并评估了96名女性志愿者当前健康状态的效用。算术能力使用先前验证的3项量表进行测量。作者研究了在不同算术水平下自我报告的健康状况与当前健康状态效用(使用标准博弈、时间权衡和视觉模拟技术评估)之间的相关性。对于一半的女性,作者还评估了3种想象中的健康状态(乳腺癌、心脏病和骨质疏松症)的标准博弈效用,并询问这些女性对每种疾病的恐惧程度。
受访者年龄在50至79岁之间(平均 = 63岁),均为高中毕业生,52%拥有大学或研究生学位。26%的人正确回答了0个或仅1个算术问题,37%的人正确回答了2个,37%的人正确回答了所有3个。在算术能力最低的女性中,当前健康状态效用与自我报告健康状况之间的相关性方向错误(即健康状况越差,评价越高):对于标准博弈,斯皮尔曼r = -0.16,P = 0.44;对于时间权衡,斯皮尔曼r = -0.13,P = 0.54。在算术能力最强的女性中,作者观察到与标准博弈(斯皮尔曼r = 0.22,P = 0.19)和时间权衡(斯皮尔曼r = 0.50,P = 0.002)均存在中等程度的正相关。相比之下,使用视觉模拟量表,作者在所有算术水平上均观察到了预期方向的显著相关性(分别回答0 - 1、2和3个算术问题的女性的斯皮尔曼r = 0.82、0.50和0.60;所有P值≤0.003)。关于想象中的健康状态,算术能力最低的女性中有35%最害怕的疾病效用最低,而算术能力最高的女性中这一比例为76%(P = 0.03)。
标准效用评估的有效性与受试者对数字的掌握程度有关。有限的算术能力可能是使用标准博弈和时间权衡技术有意义地评估患者价值观的重要障碍。