Goitein K, Michel J, Sacks T
Chemotherapy. 1975;21(3-4):181-8. doi: 10.1159/000221859.
The penetration of parenterally administered gentamicin into the CSF was examined in dogs. The experiments were carried out in three stages: (1) in healthy dogs, (2) in dogs with meningitis, and (3) during recovery from the acute inflammation. Gentamicin was found to penetrate poorly into the CSF, reaching mean peak levels of 0.7 mug/ml in healthy dogs. During the height of the meningeal inflammation the mean peak gentamicin level in the CSF was 0.9 mug/ml. The ratio of mean maximum CSF to mean maximum serum levels of gentamicin was 5.8% in healthy dogs, and 11.3% in dogs with meningitis. Thus, inflammation increases the penetration of parenterally administered gentamicin into the CSF, but therapeutically adequate levels for gram-negative bacillary meningitis are not achieved.
对犬类进行了肠胃外注射庆大霉素后其在脑脊液中渗透情况的研究。实验分三个阶段进行：（1）健康犬类；（2）患有脑膜炎的犬类；（3）急性炎症恢复期。发现庆大霉素在脑脊液中的渗透较差，在健康犬类中平均峰值水平达到0.7微克/毫升。在脑膜炎症高峰期，脑脊液中庆大霉素的平均峰值水平为0.9微克/毫升。庆大霉素在脑脊液中的平均最大水平与血清中的平均最大水平之比，在健康犬类中为5.8%，在患有脑膜炎的犬类中为11.3%。因此，炎症会增加肠胃外注射庆大霉素在脑脊液中的渗透，但对于革兰氏阴性杆菌性脑膜炎而言，无法达到治疗所需的足够水平。
