Chen I S, Chen H F, Cheng M J, Chang Y L, Teng C M, Tsutomu I, Chen J J, Tsai I L
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
J Nat Prod. 2001 Sep;64(9):1143-7. doi: 10.1021/np010122k.
Three new quinoline alkaloids, 2-acetylevolitrine (1), 2-acetylpteleine (2), and semecarpifoline (3), along with 26 known compounds were isolated from the root bark of Melicope semecarpifolia. The structures of 1-3 were elucidated by means of spectral analysis. In addition, (2S)-(--)-7,8-dimethoxyplatydesmine (4), cis-(+)-7,8-dimethoxymyrtopsine (5), and (3R)-(--)-8,9-dimethoxygeibalansine (6) were isolated as new natural products. Several of these isolates were determined as exhibiting significant antiplatelet aggregation activities in vitro.
从厚皮美蜜木的根皮中分离出三种新的喹啉生物碱，即2-乙酰基吴茱萸次碱（1）、2-乙酰基芸香亭（2）和肉豆蔻叶碱（3），以及26种已知化合物。通过光谱分析阐明了1-3的结构。此外，还分离出了新的天然产物（2S）-（-）-7,8-二甲氧基阔叶千里光碱（4）、顺式-（+）-7,8-二甲氧基桃金娘碱（5）和（3R）-（-）-8,9-二甲氧基吉巴兰辛（6）。其中几种分离物被确定在体外表现出显著的抗血小板聚集活性。
